CHAT and CAMK2A

Number of citations of the paper that reports this interaction (PMID 12486117)
4

Data Source:
HPRD (in vivo, in vitro)

		CHAT	CAMK2A
Gene Name		choline O-acetyltransferase	calcium/calmodulin-dependent protein kinase II alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Axon Neuronal Cell Body	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Choline O-acetyltransferase Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Muscle Organ Development Establishment Of Synaptic Specificity At Neuromuscular Junction Rhythmic Behavior Adult Walking Behavior Dendrite Development Neurotransmitter Biosynthetic Process Rhythmic Excitation Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Synthesis of PC Neurotransmitter Release Cycle Metabolism of lipids and lipoproteins Acetylcholine Neurotransmitter Release Cycle Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		1103	815
HPRD ID		07510	06532
Ensembl ID		ENSG00000070748	ENSG00000070808
Uniprot IDs		D3DX95 P28329 Q6LEN5 Q6LEN6	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		2FY2 2FY3 2FY4 2FY5	2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase Activity Platelet Activation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Protein Phosphorylation Activation Of Phospholipase C Activity Blood Coagulation Hemostasis Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Regulation Of Cellular Response To Insulin Stimulus Phosphorylation Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Synaptic Transmission Regulation Of Body Fluid Levels Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Activation Peptidyl-serine Phosphorylation Response To Wounding Defense Response Cell Cycle Innate Immune Response Histone H3-T6 Phosphorylation Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Phosphate-containing Compound Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Peptidyl-threonine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Protein Modification Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Signal Transduction Response To Stress Immune System Process Immune Response Mitotic Cell Cycle Process	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?		acetyltransferase choline compositions decarboxylase enk gad67 glia glutamic intensely interneurons label neurochemically neurons nmdar1 nmdar2 nmdar2a nmdar2b nmdar2c parv parvalbumin preproenkephalin preprotachykinin projection scarce som somatostatin sp striatal vulnerability	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		acetyltransferase choline compositions decarboxylase enk gad67 glia glutamic intensely interneurons label neurochemically neurons nmdar1 nmdar2 nmdar2a nmdar2b nmdar2c parv parvalbumin preproenkephalin preprotachykinin projection scarce som somatostatin sp striatal vulnerability	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?