CHAD and COL2A1

Number of citations of the paper that reports this interaction (PMID 11445564)
19

Data Source:
HPRD (in vivo, in vitro)

		CHAD	COL2A1
Gene Name		chondroadherin	collagen, type II, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function		Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Cartilage Condensation Bone Development Negative Regulation Of Bone Trabecula Formation	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: COL2A1	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		1101	1280
HPRD ID		03711	00361
Ensembl ID		ENSG00000136457	ENSG00000139219
Uniprot IDs		O15335	P02458
PDB IDs			1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Limb Bud Formation Otic Vesicle Development Embryonic Skeletal Joint Morphogenesis Embryonic Skeletal Joint Development Notochord Development Cartilage Condensation Cellular Response To BMP Stimulus Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Chondrocyte Differentiation Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Inner Ear Morphogenesis Proteoglycan Metabolic Process Palate Development Bone Morphogenesis Ear Morphogenesis Embryonic Skeletal System Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Sensory Perception Of Sound Embryonic Skeletal System Development Visual Perception Sensory Perception Of Light Stimulus Tissue Homeostasis Limb Morphogenesis Sensory Perception Of Mechanical Stimulus Inner Ear Development Cartilage Development Regulation Of Extrinsic Apoptotic Signaling Pathway Limb Development Heart Morphogenesis Bone Development Ear Development Multicellular Organismal Homeostasis Connective Tissue Development Negative Regulation Of Apoptotic Signaling Pathway Skeletal System Morphogenesis Ossification Embryonic Organ Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Glycoprotein Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		1mg 375mg 4weeks adolescence antiatherosclerotic atherogenic atherosclerosis atherosclerotic atorvastatin cameroon chronologically extract favored fecal ficus glumosa hypercholesterolemia hypolipidemic indexes leaves peroxidation precociously reflects stimulant tbars tc triglyceride vldl worsen	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		1mg 375mg 4weeks adolescence antiatherosclerotic atherogenic atherosclerosis atherosclerotic atorvastatin cameroon chronologically extract favored fecal ficus glumosa hypercholesterolemia hypolipidemic indexes leaves peroxidation precociously reflects stimulant tbars tc triglyceride vldl worsen	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?