ADIRF and RPS6KA6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ADIRF	RPS6KA6
Description		adipogenesis regulatory factor	ribosomal protein S6 kinase A6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Transcriptional regulation of white adipocyte differentiation	Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		3 interacting genes: GSK3B IL18 RPS6KA6	28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		10974	27330
HPRD ID		16575	02250
Ensembl ID		ENSG00000148671	ENSG00000072133
Uniprot IDs		Q15847	A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32
PDB IDs			6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?		TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Beta-catenin Destruction Complex Negative Regulation Of Glycogen Biosynthetic Process Superior Temporal Gyrus Development TOR Signaling Wnt Signalosome Negative Regulation Of Type B Pancreatic Cell Development ER Overload Response Protein Serine Kinase Activity Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Localization To Centrosome Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Developmental Process Regulation Of Cellular Response To Heat Positive Regulation Of Cell Adhesion Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Binding Negative Regulation Of TORC2 Signaling Maintenance Of Cell Polarity Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Cellular Response To Lipid Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of TORC2 Signaling Cellular Response To Interleukin-3 Positive Regulation Of Protein Modification Process Regulation Of Glycogen (starch) Synthase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Dynactin Binding Positive Regulation Of Protein Localization To Centrosome Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of NK T Cell Proliferation T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of T-helper 2 Cell Differentiation	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development
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