PRDX3 and CUL4B

Number of citations of the paper that reports this interaction (PubMedID 21795677)
53

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, proximity labelling technology, affinity chromatography technology)

		PRDX3	CUL4B
Description		peroxiredoxin 3	cullin 4B
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endosome Early Endosome Cytosol Plasma Membrane Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Protein Kinase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxiredoxin Activity NADH-dependent Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Maternal Placenta Development Response To Oxidative Stress Mitochondrion Organization Positive Regulation Of Cell Population Proliferation Myeloid Cell Differentiation Response To Lipopolysaccharide Negative Regulation Of Kinase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrial Membrane Potential Cellular Oxidant Detoxification	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Detoxification of Reactive Oxygen Species	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		15 interacting genes: CDC42 CUL4B FANCC GORASP2 HNRNPD MAGEA11 MAP3K13 NEK6 NR3C1 PRDX4 PTEN RPS6KC1 SUMO4 TNFRSF1A ZNF77	45 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 ST7 TBL3 UBC UBE2D3 ZMAT4
Entrez ID		10935	8450
HPRD ID		05305	02251
Ensembl ID		ENSG00000165672	ENSG00000158290
Uniprot IDs		A0A384MTR2 P30048	K4DI93 Q13620
PDB IDs		5JCG 5UCX	2DO7 4A0C 4A0L 4A64 8EI1
Enriched GO Terms of Interacting Partners?		Maternal Behavior Parental Behavior Dendritic Spine Morphogenesis Regulation Of Mitotic Cell Cycle Protein Kinase Binding Macrophage Differentiation Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Response To Stress Astrocyte Differentiation Nuclear Glucocorticoid Receptor Activity Reproductive Behavior Response To Electrical Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Branching Morphogenesis Of A Nerve	Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex
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