PRDX3 and MAP3K13

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PRDX3	MAP3K13
Description		peroxiredoxin 3	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endosome Early Endosome Cytosol Plasma Membrane Protein-containing Complex	Cytoplasm Membrane
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Protein Kinase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxiredoxin Activity NADH-dependent Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	Maternal Placenta Development Response To Oxidative Stress Mitochondrion Organization Positive Regulation Of Cell Population Proliferation Myeloid Cell Differentiation Response To Lipopolysaccharide Negative Regulation Of Kinase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrial Membrane Potential Cellular Oxidant Detoxification	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Intracellular Signal Transduction Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Detoxification of Reactive Oxygen Species
Drugs			Fostamatinib
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822) Neonatal white matter microstructure ( 33009551)
Interacting Genes		15 interacting genes: CDC42 CUL4B FANCC GORASP2 HNRNPD MAGEA11 MAP3K13 NEK6 NR3C1 PRDX4 PTEN RPS6KC1 SUMO4 TNFRSF1A ZNF77	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		10935	9175
HPRD ID		05305	05372
Ensembl ID		ENSG00000165672	ENSG00000073803
Uniprot IDs		A0A384MTR2 P30048	O43283
PDB IDs		5JCG 5UCX
Enriched GO Terms of Interacting Partners?		Maternal Behavior Parental Behavior Dendritic Spine Morphogenesis Regulation Of Mitotic Cell Cycle Protein Kinase Binding Macrophage Differentiation Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Response To Stress Astrocyte Differentiation Nuclear Glucocorticoid Receptor Activity Reproductive Behavior Response To Electrical Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Branching Morphogenesis Of A Nerve	Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Response To Cytokine Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway MAPK Cascade Negative Regulation Of Cytokine Production Involved In Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Regulation Of RNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction JNK Cascade MRNA Transcription Lactoylglutathione Lyase Activity Antigen Processing And Presentation Of Peptide Antigen Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Dentate Gyrus Mossy Fiber NADH-dependent Peroxiredoxin Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cytosol Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation
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