PRDX3 and ZNF77

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRDX3	ZNF77
Description		peroxiredoxin 3	zinc finger protein 77
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endosome Early Endosome Cytosol Plasma Membrane Protein-containing Complex	Nucleus
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Protein Kinase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxiredoxin Activity NADH-dependent Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Maternal Placenta Development Response To Oxidative Stress Mitochondrion Organization Positive Regulation Of Cell Population Proliferation Myeloid Cell Differentiation Response To Lipopolysaccharide Negative Regulation Of Kinase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrial Membrane Potential Cellular Oxidant Detoxification	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Detoxification of Reactive Oxygen Species	Generic Transcription Pathway
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Daytime sleep phenotypes ( 27126917) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		15 interacting genes: CDC42 CUL4B FANCC GORASP2 HNRNPD MAGEA11 MAP3K13 NEK6 NR3C1 PRDX4 PTEN RPS6KC1 SUMO4 TNFRSF1A ZNF77	7 interacting genes: FTO MBD3L1 METTL27 NICN1 PRDX3 RSPO4 RUSC1
Entrez ID		10935	58492
HPRD ID		05305	08936
Ensembl ID		ENSG00000165672	ENSG00000175691
Uniprot IDs		A0A384MTR2 P30048	Q15935
PDB IDs		5JCG 5UCX
Enriched GO Terms of Interacting Partners?		Maternal Behavior Parental Behavior Dendritic Spine Morphogenesis Regulation Of Mitotic Cell Cycle Protein Kinase Binding Macrophage Differentiation Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Response To Stress Astrocyte Differentiation Nuclear Glucocorticoid Receptor Activity Reproductive Behavior Response To Electrical Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Branching Morphogenesis Of A Nerve	NADH-dependent Peroxiredoxin Activity RNA Repair TRNA Demethylase Activity MRNA N6-methyladenosine Dioxygenase Activity
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