LAMTOR4

Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Late Endosome Membrane Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Cell Size Positive Regulation Of TOR Signaling TORC1 Signaling Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of TORC1 Signaling
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: USP19
Entrez ID		389541
HPRD ID		17380
Ensembl ID		ENSG00000188186
Uniprot IDs		A0A087WT92 A0A087WV46 Q0VGL1
PDB IDs		5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway Regulation Of Skeletal Muscle Tissue Development Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Organ Development Hsp90 Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress Cysteine-type Deubiquitinase Activity Protein Deubiquitination ERAD Pathway Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity
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