CD3EAP and NCL

Number of citations of the paper that reports this interaction (PMID 23145133)
4

Data Source:
BioGRID (pull down)

		CD3EAP	NCL
Gene Name		CD3e molecule, epsilon associated protein	nucleolin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	RNA Polymerase I Transcription Factor Complex Nucleus Nucleoplasm Chromosome Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm Mitochondrion	Nucleus Nucleoplasm Nucleolus Cell Cortex Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	DNA-directed RNA Polymerase Activity Poly(A) RNA Binding	Nucleotide Binding RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway RRNA Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Angiogenesis Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 23728934) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		8 interactors: CD3E NCL NFKBIB POLR1C POLR1D POLR1E TAF1A UBTF	48 interactors: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CSNK2A1 CSNK2A2 ERG ETS1 FMR1 GRB2 GZF1 GZMA H2AFX HIST1H1C HIST2H2AC HIST2H2BE HIST3H3 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PTGS1 S100A11 SREK1 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689
Entrez ID		10849	4691
HPRD ID		00125	01245
Ensembl ID		ENSG00000117877
Uniprot IDs		O15446	B3KM80 P19338 Q9BQ02
PDB IDs			2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Positive Regulation Of Type I Interferon Production Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Transcription From RNA Polymerase III Promoter Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase I Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Innate Immune Response Regulation Of Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Immune System Process Macromolecule Biosynthetic Process Immune Response Defense Response Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of T Cell Anergy Nitrogen Compound Metabolic Process Regulation Of T Cell Anergy Positive Regulation Of T Cell Tolerance Induction Negative Thymic T Cell Selection Signal Complex Assembly Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Negative T Cell Selection Chromatin Silencing At RDNA Thymic T Cell Selection	Chromosome Organization DNA Conformation Change Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Chromatin Organization Response To Stimulus Nucleobase-containing Compound Metabolic Process Cellular Response To Stress DNA Packaging Cellular Response To Stimulus Developmental Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Regulation Of Apoptotic Process Chromatin Assembly Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Regulation Of Cell Death Chromatin Assembly Or Disassembly Response To Stress Mitotic Cell Cycle Checkpoint Regulation Of Cell Proliferation DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Aging Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Aging Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process RNA Biosynthetic Process Cellular Senescence Double-strand Break Repair Protein Complex Assembly DNA Damage Checkpoint Cell Cycle Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle Process
Tagcloud ?			affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Difference) ?			affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Intersection) ?