POLR1G and CD3E

Number of citations of the paper that reports this interaction (PubMedID 10373416)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		POLR1G	CD3E
Description		RNA polymerase I subunit G	CD3 epsilon subunit of T-cell receptor complex
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GO Annotations	Cellular Component	RNA Polymerase I Transcription Regulator Complex DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Mitochondrion Cytosol	Immunological Synapse Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Dendritic Spine Cell Body
	Molecular Function	RNA Binding Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway RRNA Transcription	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of T Cell Anergy T Cell Anergy Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Calcium-mediated Signaling Cerebellum Development T Cell Costimulation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation Lymphocyte Activation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein-containing Complex Assembly Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1
Drugs			Muromonab Teplizumab Catumaxomab Mosunetuzumab Teclistamab Odronextamab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		6 interacting genes: CD3E NFKBIB POLR1C POLR1E TAF1A UBTF	26 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK EPS8L1 LCK MUC15 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1
Entrez ID		10849	916
HPRD ID		00125	08923
Ensembl ID		ENSG00000117877	ENSG00000198851
Uniprot IDs		O15446	P07766
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	1A81 1SY6 1XIW 2ROL 5QU2 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8F0L 8JC0 8JCB 8TW4 8TW6 8VY4 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase I DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Complex Fibrillar Center RNA Metabolic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Nucleolus Transcription Preinitiation Complex Assembly Nucleic Acid Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Communication By Electrical Coupling Gamma-delta T Cell Receptor Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulator Complex T Cell Anergy Regulation Of Glucose Mediated Signaling Pathway Nucleolar Large RRNA Transcription By RNA Polymerase I Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential RNA Polymerase I General Transcription Initiation Factor Activity RNA Polymerase Transcription Factor SL1 Complex Cellular Response To Magnesium Ion Positive Regulation Of T Cell Anergy Positive Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Tolerance Induction Protein-DNA Complex Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Alpha-beta T Cell Receptor Complex Signal Complex Assembly Regulation Of T Cell Anergy Transcription Elongation By RNA Polymerase I Regulation Of Delayed Rectifier Potassium Channel Activity CD4-positive, Alpha-beta T Cell Proliferation RNA Polymerase I Core Promoter Sequence-specific DNA Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Membrane Potential Protein Localization To Axon	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Complex Lymphocyte Activation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Activation Regulation Of Immune Response T Cell Activation Cell Activation Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Adaptive Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune Response Lymphocyte Differentiation Alpha-beta T Cell Receptor Complex T Cell Selection Negative Regulation Of T Cell Receptor Signaling Pathway Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mononuclear Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Thymic T Cell Selection T Cell Receptor Binding Positive T Cell Selection Leukocyte Differentiation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Gamma-delta T Cell Activation T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Beta Selection Immune Response Regulation Of Cell-cell Adhesion B Cell Activation Positive Regulation Of Cell-cell Adhesion
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