CEACAM3 and PMP22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEACAM3	PMP22
Description		CEA cell adhesion molecule 3	peripheral myelin protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Specific Granule Membrane	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Protein Binding
	Biological Process	Regulation Of Immune System Process Signal Transduction	Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		8 interacting genes: CEACAM1 CNIH3 CSNK1A1L NINJ1 NINJ2 PMP22 S100A8 SRC	64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12
Entrez ID		1084	5376
HPRD ID		16450	03059
Ensembl ID		ENSG00000170956	ENSG00000109099
Uniprot IDs		P40198	A0A2R8Y5L5 A8MU75 Q01453 Q6FH25
PDB IDs		6AVZ 6AW0 6AW1 6AW3
Enriched GO Terms of Interacting Partners?		Membrane Destabilizing Activity Cell Adhesion Cytolysis Regulation Of Innate Immune Response Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Migration Regulation Of Vascular Permeability Tissue Regeneration Regulation Of Defense Response Cell Migration Ferroptosis S100A8 Complex Regulation Of Immune Response Regulation Of Signal Transduction Regulation Of Tissue Remodeling Plasma Membrane Regulation Of Inflammatory Response Cell Motility Integrin-mediated Signaling Pathway Positive Regulation Of Defense Response Calprotectin Complex Neutrophil Aggregation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Cell Communication Negative Regulation Of Hepatocyte Proliferation Regulation Of Signaling Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Insulin Catabolic Process Leukocyte Chemotaxis Nervous System Development Regeneration Compact Myelin Peptidyl-cysteine S-nitrosylation Cellular Response To Progesterone Stimulus Cell-cell Signaling Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Homophilic Cell Adhesion Toll-like Receptor 4 Binding Connexin Binding Signaling Cellular Response To Peptide Hormone Stimulus Cell-cell Junction Regulation Of Transport Common Myeloid Progenitor Cell Proliferation Cell Junction Regulation Of Immune System Process Leukocyte Chemotaxis Involved In Inflammatory Response	Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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