CEACAM3 and S100A8

Number of citations of the paper that reports this interaction (PubMedID 11708798)
0

Data Source:
HPRD (in vivo)

		CEACAM3	S100A8
Description		CEA cell adhesion molecule 3	S100 calcium binding protein A8
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Specific Granule Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Intermediate Filament Cytoskeleton Extracellular Exosome Calprotectin Complex S100A8 Complex
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding
	Biological Process	Regulation Of Immune System Process Signal Transduction	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Peptide Secretion Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Chemotaxis Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs			Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)
Interacting Genes		8 interacting genes: CEACAM1 CNIH3 CSNK1A1L NINJ1 NINJ2 PMP22 S100A8 SRC	22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PCNA PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119
Entrez ID		1084	6279
HPRD ID		16450	00471
Ensembl ID		ENSG00000170956	ENSG00000143546
Uniprot IDs		P40198	P05109
PDB IDs		6AVZ 6AW0 6AW1 6AW3	1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2 7QUV 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Membrane Destabilizing Activity Cell Adhesion Cytolysis Regulation Of Innate Immune Response Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Migration Regulation Of Vascular Permeability Tissue Regeneration Regulation Of Defense Response Cell Migration Ferroptosis S100A8 Complex Regulation Of Immune Response Regulation Of Signal Transduction Regulation Of Tissue Remodeling Plasma Membrane Regulation Of Inflammatory Response Cell Motility Integrin-mediated Signaling Pathway Positive Regulation Of Defense Response Calprotectin Complex Neutrophil Aggregation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Cell Communication Negative Regulation Of Hepatocyte Proliferation Regulation Of Signaling Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Insulin Catabolic Process Leukocyte Chemotaxis Nervous System Development Regeneration Compact Myelin Peptidyl-cysteine S-nitrosylation Cellular Response To Progesterone Stimulus Cell-cell Signaling Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Homophilic Cell Adhesion Toll-like Receptor 4 Binding Connexin Binding Signaling Cellular Response To Peptide Hormone Stimulus Cell-cell Junction Regulation Of Transport Common Myeloid Progenitor Cell Proliferation Cell Junction Regulation Of Immune System Process Leukocyte Chemotaxis Involved In Inflammatory Response	Response To Light Stimulus Molecular Function Activator Activity PCNA-p21 Complex Enzyme Binding Response To Radiation Regulation Of Phosphorus Metabolic Process Regulation Of Growth RAGE Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Microtubule-based Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Nuclear Envelope Lumen Heparan Sulfate Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Phosphate Metabolic Process Stress-induced Premature Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Forebrain Morphogenesis Cytoskeleton-dependent Intracellular Transport Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Growth Regulation Of DNA Biosynthetic Process Replicative Senescence Synapse Maturation Cellular Response To UV Mitotic G1/S Transition Checkpoint Signaling Response To L-glutamate Structural Constituent Of Cytoskeleton Synapse Organization Protein-containing Complex Protein Serine/threonine Kinase Binding Negative Regulation Of Protein Phosphorylation Heart Development Cellular Response To Light Stimulus Circadian Behavior Rhythmic Behavior Response To Amino Acid Regulation Of DNA Replication Negative Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Dentate Gyrus Development Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Synapse Organization Positive Regulation Of Excitatory Postsynaptic Potential Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cytosol Regulation Of Cellular Response To Stress Negative Regulation Of DNA Metabolic Process
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