CPLX1 and STX1A

Number of citations of the paper that reports this interaction (PMID 7553862)
79

Data Source:
HPRD (in vivo)

		CPLX1	STX1A
Gene Name		complexin 1	syntaxin 1A (brain)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Dendrite Neuronal Cell Body Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Neurotransmitter Transporter Activity Syntaxin-1 Binding	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AGTRAP CMTM5 SNAP25 STX1A VAMP2	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		10815	6804
HPRD ID		09233	01721
Ensembl ID		ENSG00000168993	ENSG00000106089
Uniprot IDs		F1T0G1 O14810	A8MZ54 Q16623 Q75ME0
PDB IDs		3RK3 3RL0
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Vesicle Fusion Synaptic Vesicle Exocytosis Acid Secretion Organelle Fusion Dicarboxylic Acid Transport Neurotransmitter Secretion Synaptic Vesicle Transport Synaptic Vesicle Docking Positive Regulation Of Synaptic Transmission Membrane Fusion Synaptic Vesicle Fusion To Presynaptic Membrane Energy Reserve Metabolic Process Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Regulation Of Insulin Secretion Establishment Of Vesicle Localization Pathogenesis Vesicle Organization Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Establishment Of Organelle Localization Exocytosis Calcium Ion-dependent Exocytosis Long-term Synaptic Potentiation Regulation Of Protein Secretion Generation Of Precursor Metabolites And Energy Organelle Localization Organic Anion Transport Vesicle Docking Involved In Exocytosis Secretion By Cell Vesicle Docking Synaptic Transmission Membrane Docking Regulation Of Protein Transport Secretion Regulation Of Secretion Anion Transport Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Regulation Of Exocytosis Membrane Organization Regulation Of Synaptic Plasticity Cell-cell Signaling	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?			colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?			colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?