CPLX1

Description		complexin 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite SNARE Complex Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Perikaryon Calyx Of Held Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding Protein Binding Syntaxin-1 Binding Syntaxin Binding
	Biological Process	Neurotransmitter Transport Exocytosis Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Heel bone mineral density ( 30598549)
Interacting Genes		6 interacting genes: AGTRAP CMTM5 OPRM1 SNAP25 STX1A VAMP2
Entrez ID		10815
HPRD ID		09233
Ensembl ID		ENSG00000168993
Uniprot IDs		O14810
PDB IDs		3RK3 3RL0
Enriched GO Terms of Interacting Partners?		Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Calcium-ion Regulated Exocytosis SNAP Receptor Activity Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Calcium-dependent Protein Binding Voltage-gated Potassium Channel Complex Neuron Projection Vesicle-mediated Transport In Synapse Vesicle Fusion Organelle Membrane Fusion Regulated Exocytosis Regulation Of Protein Transport Synaptic Vesicle Docking SNARE Complex Assembly Organelle Fusion Synaptic Vesicle Positive Regulation Of Synaptic Transmission Regulation Of Establishment Of Protein Localization Membrane Fusion Syntaxin-1 Binding Regulation Of Secretion By Cell Signal Release Regulation Of Secretion Exocytosis Regulation Of Protein Secretion Regulation Of Hormone Secretion Synaptic Vesicle Endocytosis Vesicle Docking Involved In Exocytosis Presynaptic Endocytosis Regulation Of Protein Localization Synapse Vesicle Organization Long-term Synaptic Potentiation Vesicle Docking Secretion By Cell Axon Regulation Of Transmembrane Transporter Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Myosin Head/neck Binding Membrane Docking Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission
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