CPLX1 and CMTM5

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		CPLX1	CMTM5
Description		complexin 1	CKLF like MARVEL transmembrane domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite SNARE Complex Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Perikaryon Calyx Of Held Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Extracellular Space Membrane
	Molecular Function	SNARE Binding Protein Binding Syntaxin-1 Binding Syntaxin Binding	Cytokine Activity Protein Binding
	Biological Process	Neurotransmitter Transport Exocytosis Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Heel bone mineral density ( 30598549)
Interacting Genes		6 interacting genes: AGTRAP CMTM5 OPRM1 SNAP25 STX1A VAMP2	133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599
Entrez ID		10815	116173
HPRD ID		09233	06986
Ensembl ID		ENSG00000168993	ENSG00000166091
Uniprot IDs		O14810	Q96DZ9
PDB IDs		3RK3 3RL0
Enriched GO Terms of Interacting Partners?		Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Calcium-ion Regulated Exocytosis SNAP Receptor Activity Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Calcium-dependent Protein Binding Voltage-gated Potassium Channel Complex Neuron Projection Vesicle-mediated Transport In Synapse Vesicle Fusion Organelle Membrane Fusion Regulated Exocytosis Regulation Of Protein Transport Synaptic Vesicle Docking SNARE Complex Assembly Organelle Fusion Synaptic Vesicle Positive Regulation Of Synaptic Transmission Regulation Of Establishment Of Protein Localization Membrane Fusion Syntaxin-1 Binding Regulation Of Secretion By Cell Signal Release Regulation Of Secretion Exocytosis Regulation Of Protein Secretion Regulation Of Hormone Secretion Synaptic Vesicle Endocytosis Vesicle Docking Involved In Exocytosis Presynaptic Endocytosis Regulation Of Protein Localization Synapse Vesicle Organization Long-term Synaptic Potentiation Vesicle Docking Secretion By Cell Axon Regulation Of Transmembrane Transporter Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Myosin Head/neck Binding Membrane Docking Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission	Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity
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