NIN and PIAS1

Number of citations of the paper that reports this interaction (PMID 16154161)
3

Data Source:
HPRD (in vitro)

		NIN	PIAS1
Gene Name		ninein (GSK3B interacting protein)	protein inhibitor of activated STAT, 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleolus Centrosome Centriole Microtubule	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding GTP Binding	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Microtubule Anchoring At Centrosome Centrosome Localization Centrosome-templated Microtubule Nucleation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated JAK-STAT Cascade Spermatogenesis Protein Sumoylation Cytokine-mediated Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)	Major depressive disorder ( 23377640)
Protein-Protein Interactions		9 interactors: ABI1 AURKA BICD1 C14orf166 GSK3B PIAS1 PRKACA SUMO1 UBE2I	92 interactors: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CARM1 CASP8 CBS CEBPA CEBPE CHUK CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 ESR1 ESR2 FLI1 GATA4 GLUL GRM8 HIC1 HTT JUN L3MBTL2 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRMT1 PRMT6 PRPF40A PTK2 PTPN1 RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SIAH1 SIAH2 SKIL SMAD1 SMAD4 SMAD7 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO2 SUMO3 TBP TP53 TP73 TRIM27 TRIM55 TRIM63 UBE2I YWHAZ ZNF451 ZNF76
Entrez ID		51199	8554
HPRD ID		09785	16029
Ensembl ID		ENSG00000100503	ENSG00000033800
Uniprot IDs		Q5XUU0 Q8N4C6	O75925 Q1XBU8
PDB IDs			1V66
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Sumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Proteolysis Positive Regulation Of Proteolysis Innate Immune Response Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Binding Peptidyl-serine Phosphorylation Positive Regulation Of Protein Export From Nucleus Protein Localization To Cytoskeleton Regulation Of Protein Binding Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Cellular Protein Modification Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Export From Nucleus Defense Response Negative Regulation Of Biosynthetic Process Response To Cytokine Histone Phosphorylation Peptidyl-lysine Modification Regulation Of Signal Transduction Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Differentiation Regulation Of Immune Response Negative Regulation Of Protein Binding Positive Regulation Of Protein Modification Process Nuclear Envelope Organization Regulation Of Signaling Organelle Organization	Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Substance Macromolecule Biosynthetic Process Response To Organic Substance Cellular Response To Stimulus Regulation Of Cellular Process Multicellular Organismal Development Biosynthetic Process Response To Stimulus Regulation Of Signaling Cell Differentiation Organ Development Signaling Signal Transduction Anatomical Structure Development Developmental Process Regulation Of Signal Transduction
Tagcloud ?		3op amido arbuzov arhnp arnc carbamoyl carboxylation cnar dinickel dismantling ipr ipr2 isonitrile methacrylamide narh nhar nix ococh opr2 osime3 phosphinate pincer poc poch2 reactivities siloxide siloxido trinickel valent	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		3op amido arbuzov arhnp arnc carbamoyl carboxylation cnar dinickel dismantling ipr ipr2 isonitrile methacrylamide narh nhar nix ococh opr2 osime3 phosphinate pincer poc poch2 reactivities siloxide siloxido trinickel valent	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?