HBS1L and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HBS1L	UBE2G2
Description		HBS1 like translational GTPase	ubiquitin conjugating enzyme E2 G2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cytosolic Ribosome Extracellular Exosome Dom34-Hbs1 Complex	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Translation Translational Elongation Regulation Of Translation Signal Transduction Negative Regulation Of Gene Expression Ribosome Disassembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay Rescue Of Stalled Ribosome	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		mRNA decay by 3' to 5' exoribonuclease	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010 33339817 33547301) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 34059833) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 19862010 27863252 28017375 29403010 32888494) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hodgkin's lymphoma ( 24149102) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 19853236 19862010 20139978 23263863 27863252 28017375 28031487 28453575 28548082 29403010 32888494) Mean corpuscular hemoglobin concentration ( 20139978 23263863 27863252 28017375 29403010 32888494) Mean corpuscular volume ( 19853236 19862010 20139978 23263863 27863252 28017375 28031487 28453575 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 19853236 20139978 22139419 22423221 24026423 26805783 27863252 28031487 29066854 29403010 32888494 33545615) Plateletcrit ( 27863252 32888494) Red blood cell count ( 20139978 27863252 28017375 28031487 28453575 29403010 32888494) Red blood cell traits ( 20927387 23222517 23935956) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 20139978 27863252 29403010 32888494) White blood cell types ( 21738478)	Alanine aminotransferase levels ( 33547301)
Interacting Genes		8 interacting genes: APP EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBC UBE2G2	41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		10767	7327
HPRD ID		06582	04387
Ensembl ID		ENSG00000112339	ENSG00000184787
Uniprot IDs		B7Z524 D9YZV0 Q9Y450	P60604
PDB IDs		5LZW 5LZX 5LZY 5LZZ 9G8M 9G8N 9G8O 9G8P 9G8R	2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process RRNA Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Modification Process Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity RNA Surveillance MRNA Metabolic Process Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Viral Genome Replication Nucleoside-triphosphatase Regulator Activity Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Protein Serine/threonine Kinase Activity Macromolecule Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome Dom34-Hbs1 Complex MRNA Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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