HBS1L and EXOSC9

Number of citations of the paper that reports this interaction (PubMedID 27345150)
56

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HBS1L	EXOSC9
Description		HBS1 like translational GTPase	exosome component 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cytosolic Ribosome Extracellular Exosome Dom34-Hbs1 Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Translation Translational Elongation Regulation Of Translation Signal Transduction Negative Regulation Of Gene Expression Ribosome Disassembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay Rescue Of Stalled Ribosome	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		mRNA decay by 3' to 5' exoribonuclease	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010 33339817 33547301) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 34059833) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 19862010 27863252 28017375 29403010 32888494) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hodgkin's lymphoma ( 24149102) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 19853236 19862010 20139978 23263863 27863252 28017375 28031487 28453575 28548082 29403010 32888494) Mean corpuscular hemoglobin concentration ( 20139978 23263863 27863252 28017375 29403010 32888494) Mean corpuscular volume ( 19853236 19862010 20139978 23263863 27863252 28017375 28031487 28453575 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 19853236 20139978 22139419 22423221 24026423 26805783 27863252 28031487 29066854 29403010 32888494 33545615) Plateletcrit ( 27863252 32888494) Red blood cell count ( 20139978 27863252 28017375 28031487 28453575 29403010 32888494) Red blood cell traits ( 20927387 23222517 23935956) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 20139978 27863252 29403010 32888494) White blood cell types ( 21738478)	Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APP EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBC UBE2G2	21 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 ERG EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MTREX PALS2 SETX SUMO2 UBE2I ZDHHC17
Entrez ID		10767	5393
HPRD ID		06582	07315
Ensembl ID		ENSG00000112339	ENSG00000123737
Uniprot IDs		B7Z524 D9YZV0 Q9Y450	B4DXG8 Q06265
PDB IDs		5LZW 5LZX 5LZY 5LZZ 9G8M 9G8N 9G8O 9G8P 9G8R	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process RRNA Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Modification Process Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity RNA Surveillance MRNA Metabolic Process Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Viral Genome Replication Nucleoside-triphosphatase Regulator Activity Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Protein Serine/threonine Kinase Activity Macromolecule Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome Dom34-Hbs1 Complex MRNA Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear RNA Surveillance RNA Surveillance MRNA Catabolic Process SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nucleobase-containing Compound Catabolic Process SnRNA Processing RRNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Macromolecule Catabolic Process 3'-5'-RNA Exonuclease Activity RNA Metabolic Process RNA Processing RNA Binding RNA 3'-end Processing Sno(s)RNA Metabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RRNA 3'-end Processing TRNA Decay DNA Deamination Catabolic Process Nucleolus Nucleobase-containing Compound Metabolic Process CUT Catabolic Process Nucleoplasm DNA Modification Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding Nucleus Negative Regulation Of Macromolecule Biosynthetic Process
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