POLD3 and POLD2

Number of citations of the paper that reports this interaction (PMID 10852724)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		POLD3	POLD2
Gene Name		polymerase (DNA-directed), delta 3, accessory subunit	polymerase (DNA directed), delta 2, accessory subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Delta DNA Polymerase Complex	Nucleus Nucleoplasm
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755)
Protein-Protein Interactions		7 interactors: APP MBD3L2 PCNA POLD1 POLD2 POLD4 SPRTN	16 interactors: CCHCR1 CDK2 CDKN1A EP300 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 SOX12 WRN WRNIP1 XRN1
Entrez ID		10714	5425
HPRD ID		11446	15982
Ensembl ID		ENSG00000077514	ENSG00000106628
Uniprot IDs		Q15054	A4D2J4 B2R5S4 P49005
PDB IDs		1U76 3E0J	3E0J
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Biosynthetic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Mismatch Repair Base-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication DNA Repair Cellular Homeostasis DNA Recombination DNA Replication Cellular Response To DNA Damage Stimulus DNA Metabolic Process Translesion Synthesis Homeostatic Process Cellular Response To Stress Response To Stress Postreplication Repair Mitotic Cell Cycle Chromosome Organization Cell Cycle Process Nucleobase-containing Compound Metabolic Process Response To Light Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Cell Cycle Nitrogen Compound Metabolic Process DNA Replication Proofreading Positive Regulation Of Deoxyribonuclease Activity Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To UV Cellular Response To Stimulus Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Base-excision Repair, Gap-filling	DNA Replication DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Base-excision Repair Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Telomere Maintenance Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Repair Mismatch Repair Chromosome Organization Cellular Response To Stress DNA Metabolic Process Mitotic Cell Cycle DNA Recombination Nucleotide-excision Repair Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Response To Stress Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Macromolecule Biosynthetic Process Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Response To UV Positive Regulation Of DNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Mitochondrion Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Biosynthetic Process
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo sumo1 sumo2 sumo3 sumoylation
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo sumo1 sumo2 sumo3 sumoylation
Tagcloud (Intersection) ?