POLD3 and POLD4

Number of citations of the paper that reports this interaction (PubMedID 16510448)
0

Data Source:
BioGRID (pull down)

		POLD3	POLD4
Description		DNA polymerase delta 3, accessory subunit	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleus Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response Error-prone Translesion Synthesis DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair	DNA Synthesis Involved In DNA Repair Positive Regulation Of Endothelial Cell Proliferation DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755 25990418 26151821 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29313844 29691431) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		7 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		10714	57804
HPRD ID		11446	17873
Ensembl ID		ENSG00000077514	ENSG00000175482
Uniprot IDs		Q15054	Q6NSD7 Q9HCU8
PDB IDs		1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Translesion Synthesis Delta DNA Polymerase Complex Postreplication Repair DNA Replication DNA-directed DNA Polymerase Activity DNA Repair DNA-templated DNA Replication Error-free Translesion Synthesis Damaged DNA Binding DNA Metabolic Process Response To Light Stimulus DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Error-prone Translesion Synthesis DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Response To Radiation DNA Strand Elongation Response To UV Macromolecule Biosynthetic Process Cellular Response To Stress Response To Stress Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway PCNA Complex Replisome Nucleic Acid Metabolic Process Deoxycytidyl Transferase Activity DNA Binding Cellular Response To UV Nucleotidyltransferase Activity Chromatin Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Cellular Response To Light Stimulus Purine-specific Mismatch Base Pair DNA N-glycosylase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production	DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Translesion Synthesis Postreplication Repair DNA Repair DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process DNA Strand Elongation DNA Damage Response Delta DNA Polymerase Complex Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Biosynthetic Process Base-excision Repair, Gap-filling Cellular Response To Stress DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process DNA Replication Proofreading Macromolecule Biosynthetic Process Chromosome, Telomeric Region Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Metabolic Process Response To Stress Error-prone Translesion Synthesis DNA Polymerase Activity Response To Radiation Response To UV Chromatin Binding Mismatch Repair 4 Iron, 4 Sulfur Cluster Binding Macromolecule Metabolic Process PCNA Complex Damaged DNA Binding Replisome Response To Light Stimulus Iron-sulfur Cluster Binding Nucleoplasm Cellular Response To UV PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotidyltransferase Activity Cellular Response To Light Stimulus Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of DNA Replication DNA Synthesis Involved In UV-damage Excision Repair Regulation Of DNA Metabolic Process
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