POLD3 and POLD4

Number of citations of the paper that reports this interaction (PMID 16510448)
23

Data Source:
BioGRID (pull down)

		POLD3	POLD4
Gene Name		polymerase (DNA-directed), delta 3, accessory subunit	polymerase (DNA-directed), delta 4, accessory subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Delta DNA Polymerase Complex	Nucleus Nucleoplasm
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755)
Protein-Protein Interactions		7 interactors: APP MBD3L2 PCNA POLD1 POLD2 POLD4 SPRTN	7 interactors: PCNA POLD1 POLD2 POLD3 POLE SEC23IP WRNIP1
Entrez ID		10714	57804
HPRD ID		11446	17873
Ensembl ID		ENSG00000077514
Uniprot IDs		Q15054	Q6NSD7 Q9HCU8
PDB IDs		1U76 3E0J
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Biosynthetic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Mismatch Repair Base-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication DNA Repair Cellular Homeostasis DNA Recombination DNA Replication Cellular Response To DNA Damage Stimulus DNA Metabolic Process Translesion Synthesis Homeostatic Process Cellular Response To Stress Response To Stress Postreplication Repair Mitotic Cell Cycle Chromosome Organization Cell Cycle Process Nucleobase-containing Compound Metabolic Process Response To Light Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Cell Cycle Nitrogen Compound Metabolic Process DNA Replication Proofreading Positive Regulation Of Deoxyribonuclease Activity Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To UV Cellular Response To Stimulus Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Base-excision Repair, Gap-filling	Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Base-excision Repair DNA Synthesis Involved In DNA Repair Telomere Maintenance DNA Replication Nucleotide-excision Repair DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mismatch Repair DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Homeostasis Cellular Response To Stress Mitotic Cell Cycle Base-excision Repair, Gap-filling Chromosome Organization Cell Cycle Process Cell Cycle Homeostatic Process Organelle Organization Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Deoxyribonuclease Activity DNA Replication Proofreading Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Leading Strand Elongation Regulation Of DNA Replication Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Phase Transition Cellular Response To Stimulus Translesion Synthesis Fatty Acid Homeostasis
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo sumo1 sumo2 sumo3 sumoylation
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo sumo1 sumo2 sumo3 sumoylation
Tagcloud (Intersection) ?