POLD3 and MBD3L2

Number of citations of the paper that reports this interaction (PubMedID 15701600)
0

Data Source:
BioGRID (pull down)

		POLD3	MBD3L2
Description		DNA polymerase delta 3, accessory subunit	methyl-CpG binding domain protein 3 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleus
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Methyl-CpG Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response Error-prone Translesion Synthesis DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Regulation Of Chromatin Organization
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755 25990418 26151821 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29313844 29691431) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)
Interacting Genes		7 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1	12 interacting genes: CCDC136 GOLGA6L9 GPRASP2 KRT27 KRT34 KRTAP6-3 MBD2 MDFI POLD3 RUNDC3A SBK3 TRIML2
Entrez ID		10714	125997
HPRD ID		11446	12139
Ensembl ID		ENSG00000077514	ENSG00000230522
Uniprot IDs		Q15054	Q8NHZ7
PDB IDs		1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Translesion Synthesis Delta DNA Polymerase Complex Postreplication Repair DNA Replication DNA-directed DNA Polymerase Activity DNA Repair DNA-templated DNA Replication Error-free Translesion Synthesis Damaged DNA Binding DNA Metabolic Process Response To Light Stimulus DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Error-prone Translesion Synthesis DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Response To Radiation DNA Strand Elongation Response To UV Macromolecule Biosynthetic Process Cellular Response To Stress Response To Stress Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway PCNA Complex Replisome Nucleic Acid Metabolic Process Deoxycytidyl Transferase Activity DNA Binding Cellular Response To UV Nucleotidyltransferase Activity Chromatin Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Cellular Response To Light Stimulus Purine-specific Mismatch Base Pair DNA N-glycosylase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production	Intermediate Filament
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?