SIRT7 and USP17L2

Number of citations of the paper that reports this interaction (PubMedID 36040642)
0

Data Source:
BioGRID (enzymatic study)

		SIRT7	USP17L2
Description		sirtuin 7	ubiquitin specific peptidase 17 like family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Chromatin Binding Protein Binding Protein Methyltransferase Activity Transferase Activity Hydrolase Activity NAD-dependent Protein Lysine Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Protein Deacetylation DNA Damage Response Homologous Chromosome Pairing At Meiosis RRNA Transcription Transposable Element Silencing Regulation Of Mitochondrion Organization Negative Regulation Of Protein Ubiquitination Epigenetic Regulation Of Gene Expression Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Protein Export From Nucleus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Deglutarylation R-loop Processing Protein Depropionylation DNA Repair-dependent Chromatin Remodeling Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of RRNA Processing	MAPK Cascade Proteolysis Apoptotic Process Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways			Ub-specific processing proteases RAS processing
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 KAT2B MAGED1 NPM1 POLR1E PPARG RRP9 USP17L2 USP39 WDR77	11 interacting genes: BRD4 CDK4 CDK6 ELK1 KLF4 KMT5A LGMN LINC02487 SIRT7 UBC ZBTB7A
Entrez ID		51547	377630
HPRD ID		12094	16844
Ensembl ID		ENSG00000187531	ENSG00000223443
Uniprot IDs		Q9NRC8	Q6R6M4
PDB IDs		5IQZ 6G0S 9GMK 9GMR
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleus Chromatin Organization Protein-containing Complex Assembly Nucleosome Assembly Nucleosome Nucleosome Organization Protein-containing Complex Organization Protein Heterodimerization Activity Negative Regulation Of Cell Population Proliferation Protein-containing Complex Negative Regulation Of Centrosome Duplication Epigenetic Regulation Of Gene Expression Transcription Coactivator Activity Negative Regulation Of Gene Expression Regulation Of Cell Population Proliferation Positive Regulation Of Glycolytic Process Nucleoplasm Regulation Of Centriole Replication Negative Regulation Of MiRNA Transcription Cellular Component Assembly Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of RNA Splicing DNA-binding Transcription Factor Binding Positive Regulation Of Fatty Acid Metabolic Process Chromatin Binding Regulation Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Centrosome Duplication RNA Polymerase I General Transcription Initiation Factor Binding Oocyte Axis Specification Macromolecule Metabolic Process	Regulation Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Chromatin Remodeling Histone H4K8ac Reader Activity Nucleolus Organizer Region Polytene Chromosome Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Response To Growth Factor Negative Regulation Of Signal Transduction
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