SIRT7

Gene Name		sirtuin 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Nucleolus Organizer Region Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Metal Ion Binding NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription On Exit From Mitosis RRNA Transcription Histone H3 Deacetylation Histone H4 Deacetylation
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: APP HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MAGED1
Entrez ID		51547
HPRD ID		12094
Ensembl ID		ENSG00000187531
Uniprot IDs		Q9NRC8
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly Chromatin Assembly DNA Methylation On Cytosine Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Silencing At RDNA Protein-DNA Complex Assembly DNA Packaging Chromatin Silencing DNA Conformation Change DNA Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Cellular Macromolecular Complex Assembly Synaptic Growth At Neuromuscular Junction Chromatin Organization Cellular Component Assembly Collateral Sprouting In Absence Of Injury Histone H4-K20 Demethylation Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Protein Complex Assembly Axon Choice Point Recognition Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Methylation Innate Immune Response In Mucosa Blood Coagulation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Cellular Copper Ion Homeostasis Hemostasis Regulation Of Megakaryocyte Differentiation Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle CENP-A Containing Nucleosome Assembly
Tagcloud ?		advanced aimed altered biomarkers carcinoma circulating family head healthy hnscc individuals leukocytes markers neck pb peripheral possibility postoperative profiles prognostic recovery regulated sirt1 sirt3 sirt6 squamous stage surgery