CETN2 and XPC

Number of citations of the paper that reports this interaction (PubMedID 34591612)
132

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CETN2	XPC
Description		centrin 2	XPC complex subunit, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Nuclear Pore Nuclear Basket Apical Part Of Cell Transcription Export Complex 2 XPC Complex Glial Cell Projection 9+2 Motile Cilium	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane XPC Complex Site Of DNA Damage
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Metal Ion Binding	Heteroduplex DNA Loop Binding Bubble DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Damage Sensor Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle DNA Repair Nucleotide-excision Repair DNA Damage Response Centriole Replication Spermatogenesis Protein Transport Regulation Of Cytokinesis MRNA Transport Cell Division	Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Mismatch Repair DNA Damage Response Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Response To UV-B Response To Auditory Stimulus Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription UV-damage Excision Repair Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA damage response and repair proteins Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER AURKA Activation by TPX2	SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Serum alkaline phosphatase levels ( 33339817)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: ARSA CCP110 PNMA5 PRMT6 SFI1 UBC XPC	17 interacting genes: BTG3 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMC5 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B
Entrez ID		1069	7508
HPRD ID		02051	02046
Ensembl ID		ENSG00000147400	ENSG00000154767
Uniprot IDs		P41208	Q01831 X5DRB1
PDB IDs		1M39 1ZMZ 2A4J 2GGM 2K2I 2OBH 8EBS 8EBT 8EBV 8EBW 8EBX 8J07	2A4J 2GGM 2OBH 2RVB 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY
Enriched GO Terms of Interacting Partners?			Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Nucleoplasm Cellular Response To Stress Nucleic Acid Metabolic Process Macromolecule Metabolic Process Proteasome Complex Nucleus Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process XPC Complex Base-excision Repair Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process UV-damage Excision Repair UV Protection Transcription Factor TFIIH Core Complex Transcription-coupled Nucleotide-excision Repair Proteasome Regulatory Particle, Base Subcomplex Transcription Factor TFIIH Holo Complex DNA Replication Factor A Complex Cellular Response To UV Proteasomal Protein Catabolic Process Proteasome Accessory Complex Ubiquitin Binding Proteasome Binding Cellular Response To Light Stimulus Single-stranded DNA Binding PML Body Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Radiation Site Of DNA Damage Response To Radiation Protein-containing Complex Nucleotide-excision Repair Factor 3 Complex
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