PNMA2 and THAP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PNMA2	THAP7
Description		PNMA family member 2	THAP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane
	Molecular Function	Protein Binding	Transcription Corepressor Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Histone H4 Reader Activity General Transcription Initiation Factor Binding Histone Reader Activity
	Biological Process	Positive Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		32 interacting genes: BYSL CBX8 CCDC33 CDC37 CNNM3 ENKD1 FAM161A GPATCH2L HAPLN2 INO80B LRR1 MISP MORF4L2 NTAQ1 PPIG PRPF31 PSMA1 RNF6 RNF8 RPL9 RSPH1 RTP5 SCNM1 SDCBP THAP7 TOP3B TTLL10 ZNF408 ZNF417 ZNF587 ZNF669 ZNF688	63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1
Entrez ID		10687	80764
HPRD ID		04915	15500
Ensembl ID		ENSG00000240694	ENSG00000184436
Uniprot IDs		Q5U5Z3 Q9UL42	Q9BT49
PDB IDs		8UYO
Enriched GO Terms of Interacting Partners?		Nucleus	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Thioesterase Binding Protein Binding Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Regulation Of Toll Signaling Pathway Cytosol Intermediate Filament Organization Protein-containing Complex Disassembly Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Wnt Signaling Pathway Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Protein Serine/threonine Phosphatase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Nitrogen Starvation Cytoskeleton CD40 Receptor Complex
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