TGOLN2 and AP4M1

Number of citations of the paper that reports this interaction (PubMedID 9794796)
33

Data Source:
HPRD (in vitro)

		TGOLN2	AP4M1
Description		trans-golgi network protein 2	adaptor related protein complex 4 subunit mu 1
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GO Annotations	Cellular Component	Nucleoplasm Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Transport Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane	Cytoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Protein Domain Specific Binding
	Biological Process		Autophagosome Assembly Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Transmembrane Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Golgi Associated Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation	Lysosome Vesicle Biogenesis
Drugs
Diseases			Cerebral palsy
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: AP1M1 AP1M2 AP2M1 AP3M1 AP4M1 CRYAA ITGB1 KRTAP10-9 PPP1R9A PPP1R9B PRKD2	16 interacting genes: ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B HOOK1 HOOK2 KRTAP5-2 LAMP2 TGOLN2 USP47 ZBTB22
Entrez ID		10618	9179
HPRD ID		04343	03803
Ensembl ID		ENSG00000152291	ENSG00000221838
Uniprot IDs		A0A5F9UY30 O43493	C9JC87 C9JWL4 H7C0A0 O00189
PDB IDs		6YAF	3L81 4MDR
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Clathrin Adaptor Activity Receptor Internalization Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Intracellular Protein Transport Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Actin Filament Organization Filopodium AP-1 Adaptor Complex Vesicle-mediated Transport Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Melanosome Assembly Lysosomal Membrane Dendritic Spine Platelet Dense Granule Organization Regulation Of Protein Localization To Cell Periphery Plasma Membrane Bounded Cell Projection Synapse Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Establishment Of Localization In Cell Cytoplasmic Vesicle Membrane Protein Targeting To Lysosome Supramolecular Fiber Organization Cellular Component Assembly Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Clathrin-coated Vesicle Membrane Regulation Of Cellular Localization Melanosome Organization Pigment Granule Organization Protein Targeting Protein Transport Intracellular Protein Localization Protein Targeting To Vacuole Intracellular Transport Myoblast Fate Specification Integrin Alpha7-beta1 Complex Protein Localization To Lysosome Cortical Actin Cytoskeleton Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Establishment Of Protein Localization Establishment Of Protein Localization To Vacuole Positive Regulation Of Protein Localization To Plasma Membrane Secretory Granule Organization Golgi Apparatus Vesicle Organization	Postsynaptic Density Membrane Ligand-gated Monoatomic Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential FHF Complex Synaptic Transmission, Glutamatergic Intracellular Protein Localization Platelet Dense Granule Membrane Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Protein Localization To Perinuclear Region Of Cytoplasm Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Excitatory Chemical Synaptic Transmission Cellular Localization Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Ion Transmembrane Transport Calcium Ion Transport HOPS Complex Modulation Of Chemical Synaptic Transmission Somatodendritic Compartment Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Transport Lysosomal Transport Inorganic Cation Transmembrane Transport Early Endosome To Late Endosome Transport Monoatomic Cation Transmembrane Transport AMPA Glutamate Receptor Complex Dynein Light Intermediate Chain Binding Positive Regulation Of Synaptic Transmission Late Endosome Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Inorganic Ion Transmembrane Transport Protein Localization To Postsynapse Transmembrane Transport Monoatomic Ion Channel Activity Vacuolar Transport Monoatomic Cation Transport Trans-Golgi Network Mitotic Cleavage Furrow Ingression Pigment Granule Maturation Peptide Pheromone Maturation Chaperone-mediated Autophagy Translocation Complex Establishment Of Protein Localization
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