TGOLN2 and PRKD2

Number of citations of the paper that reports this interaction (PubMedID 14743217)
28

Data Source:
HPRD (in vitro)

		TGOLN2	PRKD2
Description		trans-golgi network protein 2	protein kinase D2
Image
GO Annotations	Cellular Component	Nucleoplasm Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Transport Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process		Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Protein Phosphorylation Cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Sphingolipid Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Regulation Of T Cell Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Golgi Associated Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Post bronchodilator FEV1 ( 26634245) Primary sclerosing cholangitis ( 23603763 27992413)
Interacting Genes		11 interacting genes: AP1M1 AP1M2 AP2M1 AP3M1 AP4M1 CRYAA ITGB1 KRTAP10-9 PPP1R9A PPP1R9B PRKD2	17 interacting genes: CASK DST GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2 VPS26C
Entrez ID		10618	25865
HPRD ID		04343	09523
Ensembl ID		ENSG00000152291	ENSG00000105287
Uniprot IDs		A0A5F9UY30 O43493	Q9BZL6
PDB IDs		6YAF	2COA 3BGM 4NNX 4NNY
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Clathrin Adaptor Activity Receptor Internalization Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Intracellular Protein Transport Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Actin Filament Organization Filopodium AP-1 Adaptor Complex Vesicle-mediated Transport Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Melanosome Assembly Lysosomal Membrane Dendritic Spine Platelet Dense Granule Organization Regulation Of Protein Localization To Cell Periphery Plasma Membrane Bounded Cell Projection Synapse Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Establishment Of Localization In Cell Cytoplasmic Vesicle Membrane Protein Targeting To Lysosome Supramolecular Fiber Organization Cellular Component Assembly Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Clathrin-coated Vesicle Membrane Regulation Of Cellular Localization Melanosome Organization Pigment Granule Organization Protein Targeting Protein Transport Intracellular Protein Localization Protein Targeting To Vacuole Intracellular Transport Myoblast Fate Specification Integrin Alpha7-beta1 Complex Protein Localization To Lysosome Cortical Actin Cytoskeleton Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Establishment Of Protein Localization Establishment Of Protein Localization To Vacuole Positive Regulation Of Protein Localization To Plasma Membrane Secretory Granule Organization Golgi Apparatus Vesicle Organization
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