ATG14 and ATG13

Number of citations of the paper that reports this interaction (PubMedID 27046250)
55

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ATG14	ATG13
Description		autophagy related 14	autophagy related 13
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Axoneme Membrane Cytoplasmic Vesicle Protein-containing Complex Phagophore Assembly Site Membrane Phosphatidylinositol 3-kinase Complex, Class III Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Membrane Cytosol Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity Protein-membrane Adaptor Activity GTPase Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Autophagosome Assembly Mitophagy Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Targeting To Lysosome Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Post-transcriptional Regulation Of Gene Expression Macroautophagy Autophagosome Membrane Docking Regulation Of Macroautophagy Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Early Endosome To Late Endosome Transport Innate Immune Response Defense Response To Virus Regulation Of Protein Complex Stability Regulation Of Triglyceride Metabolic Process Autophagosome Maturation Response To Mitochondrial Depolarisation	Autophagosome Assembly Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Regulation Of Cell Population Proliferation Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Macroautophagy SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Macroautophagy
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Platelet distribution width ( 27863252) Statin-induced myopathy ( 31220337) Testicular germ cell tumor ( 28604728) White blood cell count ( 32888494)	Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)
Interacting Genes		14 interacting genes: ATG13 EXOC1 FSD2 MARCHF7 MIS18A OTUD3 OTUD7B RACK1 SNAPIN STAMBP STYK1 ULK2 USP2 YOD1	13 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C OTOS RNF31 SMCR8 ULK1
Entrez ID		22863	9776
HPRD ID		13820	13809
Ensembl ID		ENSG00000126775	ENSG00000175224
Uniprot IDs		Q6ZNE5	A8K0S6 O75143
PDB IDs		6HOL 8SOR 9C82 9MHF 9MHG 9MHH	3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN 8DO8 8SOI 8SQZ 8SRM 9C82
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Cysteine-type Deubiquitinase Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Protein K27-linked Deubiquitination Protein Modification Process Peptidase Activity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Piecemeal Microautophagy Of The Nucleus K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Metabolic Process Phagophore Assembly Site Membrane Microautophagy Nucleophagy Perinuclear Region Of Cytoplasm Deubiquitinase Activity Negative Regulation Of Intracellular Signal Transduction Macroautophagy Phagophore Assembly Site Cyclin Binding Vacuole Organization Negative Regulation Of Cell Projection Organization Cytosol Rescue Of Stalled Ribosome Ribosome Disassembly Cytoplasm Somatic Sensory System Development Positive Regulation Of Late Endosome To Lysosome Transport Protein Stabilization Mitophagy Translational Elongation Mitotic Cytokinesis Autophagy Autophagy Of Mitochondrion IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Negative Regulation Of Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Organelle Disassembly Autophagosome Negative Regulation Of Cellular Component Organization Hippocampal Neuron Apoptotic Process Protein K6-linked Deubiquitination Pericentric Heterochromatin Organization	Mitophagy Autophagosome Membrane Autophagosome Organization Autophagosome Assembly Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Autophagosome Autophagy Vacuole Organization Autophagosome Maturation Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Cellular Response To Starvation Phospholipid Binding Organelle Assembly Response To Nutrient Levels Ubiquitin Protein Ligase Binding Atg1/ULK1 Kinase Complex Cytoplasmic Vesicle Catabolic Process Protein-containing Complex Organization GABA Receptor Binding Cellular Component Assembly Phagophore Assembly Site Positive Regulation Of Catabolic Process Microtubule Beta-tubulin Binding Cellular Response To Stress Organelle Membrane Regulation Of Autophagy Response To Stress Positive Regulation Of Autophagy Regulation Of Macroautophagy Organelle Organization Microtubule Binding Endomembrane System Positive Regulation Of Macroautophagy Response To Lead Ion Axoneme Cytosol Phagophore Assembly Site Membrane Cellular Response To Copper Ion Cytoplasm Response To Copper Ion GTPase Binding Regulation Of Autophagosome Assembly Amyloid-beta Complex
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