ATG14 and YOD1

Number of citations of the paper that reports this interaction (PubMedID 37632749)
0

Data Source:
BioGRID (enzymatic study)

		ATG14	YOD1
Description		autophagy related 14	YOD1 deubiquitinase
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GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Axoneme Membrane Cytoplasmic Vesicle Protein-containing Complex Phagophore Assembly Site Membrane Phosphatidylinositol 3-kinase Complex, Class III Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity Protein-membrane Adaptor Activity GTPase Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Autophagosome Assembly Mitophagy Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Targeting To Lysosome Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Post-transcriptional Regulation Of Gene Expression Macroautophagy Autophagosome Membrane Docking Regulation Of Macroautophagy Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Early Endosome To Late Endosome Transport Innate Immune Response Defense Response To Virus Regulation Of Protein Complex Stability Regulation Of Triglyceride Metabolic Process Autophagosome Maturation Response To Mitochondrial Depolarisation	Proteolysis Response To Unfolded Protein Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways		Macroautophagy SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Platelet distribution width ( 27863252) Statin-induced myopathy ( 31220337) Testicular germ cell tumor ( 28604728) White blood cell count ( 32888494)	Systolic blood pressure ( 28234671)
Interacting Genes		14 interacting genes: ATG13 EXOC1 FSD2 MARCHF7 MIS18A OTUD3 OTUD7B RACK1 SNAPIN STAMBP STYK1 ULK2 USP2 YOD1	30 interacting genes: ATG14 BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 ZFP57
Entrez ID		22863	55432
HPRD ID		13820	10312
Ensembl ID		ENSG00000126775	ENSG00000180667
Uniprot IDs		Q6ZNE5	Q5VVQ6
PDB IDs		6HOL 8SOR 9C82 9MHF 9MHG 9MHH	4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Cysteine-type Deubiquitinase Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Protein K27-linked Deubiquitination Protein Modification Process Peptidase Activity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Piecemeal Microautophagy Of The Nucleus K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Metabolic Process Phagophore Assembly Site Membrane Microautophagy Nucleophagy Perinuclear Region Of Cytoplasm Deubiquitinase Activity Negative Regulation Of Intracellular Signal Transduction Macroautophagy Phagophore Assembly Site Cyclin Binding Vacuole Organization Negative Regulation Of Cell Projection Organization Cytosol Rescue Of Stalled Ribosome Ribosome Disassembly Cytoplasm Somatic Sensory System Development Positive Regulation Of Late Endosome To Lysosome Transport Protein Stabilization Mitophagy Translational Elongation Mitotic Cytokinesis Autophagy Autophagy Of Mitochondrion IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Negative Regulation Of Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Organelle Disassembly Autophagosome Negative Regulation Of Cellular Component Organization Hippocampal Neuron Apoptotic Process Protein K6-linked Deubiquitination Pericentric Heterochromatin Organization	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein-containing Complex Protein K48-linked Ubiquitination Zinc Ion Binding Cytoplasm Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coactivator Activity Identical Protein Binding Proteolysis Proteolysis Involved In Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Signal Transduction Nucleus Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Nuclear Body Positive Regulation Of Protein Modification Process Regulation Of Defense Response Transferase Activity Negative Regulation Of Necroptotic Process Response To Other Organism Regulation Of RIG-I Signaling Pathway Negative Regulation Of Programmed Necrotic Cell Death Protein Catabolic Process Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process
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