PDLIM5 and COIL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PDLIM5	COIL
Description		PDZ and LIM domain 5	coilin
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Filamentous Actin Cell Projection Synapse Presynapse Postsynapse	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Nuclear Body
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Actinin Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding U1 SnRNA Binding U2 SnRNA Binding Identical Protein Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Muscle Structure Development Cell-cell Adhesion	Spliceosomal SnRNP Assembly
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lewy body disease ( 25188341) Mean platelet volume ( 27863252 32888494) Myocardial infarction ( 33532862) PR interval ( 32439900) Prostate cancer ( 19767753) Pulse pressure ( 30578418) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Uterine fibroids ( 31649266) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 28552196)	Height ( 18391951)
Interacting Genes		15 interacting genes: ACTB ACTN1 CACNA1B CCDC136 COIL DSCAM GFI1B KRT40 KRTAP10-7 NOD2 PRKCB PRKCE PRKCG TRIM39 ZYX	84 interacting genes: ACTN1 ACTN2 ACTN4 ADAMTS12 APP ARMCX1 ATXN1 ATXN1L BYSL C1QBP C9orf72 CCDC136 CCDC159 CCDC57 CCNE1 CDC23 CDK2 CEP70 CEP76 CSNK2B CYB5R2 DHX16 DNAJA3 DRG1 DYNC2I2 ELOA2 FGF12 FHL5 FXR1 FXR2 GCC1 HSF2BP KALRN KAZN KDM1A KLC2 KLC4 KLHL42 KLHL8 KPNA3 LNX1 MAD1L1 MCRS1 MYO15B MYO5B NFU1 NIF3L1 NKAPD1 NOLC1 NTAQ1 NUDT18 OGT PDE4D PDLIM5 PIAS4 PICK1 PLEKHG4 PLOD3 POLR2L POLR3C PREPL PRMT1 PRMT8 PSMA1 PSME3 PTS SART3 SCYL1 SMN1 SNRPB SNRPF SNX6 SPANXN2 SRPK2 TAF9 TCAF1 TFCP2 TGS1 TSPYL2 XRCC5 XRCC6 ZBTB25 ZCCHC10 ZNF277
Entrez ID		10611	8161
HPRD ID		05799	02605
Ensembl ID		ENSG00000163110	ENSG00000121058
Uniprot IDs		A0A0A0MSP3 B7Z481 B7Z8X5 Q96HC4	P38432
PDB IDs		2DAR 2UZC
Enriched GO Terms of Interacting Partners?		Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Cell Adhesion Synapse Regulation Of Neurotransmitter Secretion Response To Morphine Cell-cell Signaling Signaling Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Regulation Of Canonical NF-kappaB Signal Transduction Trans-synaptic Signaling Cell Communication Synaptic Signaling Positive Regulation Of Synaptic Transmission Presynaptic Cytosol Plasma Membrane Cell-cell Adhesion Cell-cell Junction Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Cytochalasin B Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Protein Ubiquitination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding ATP Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Brush Border Regulation Of Vesicle-mediated Transport Regulation Of Post-translational Protein Modification Cytoskeleton Cell Junction Assembly Regulation Of Norepinephrine Uptake Homotypic Cell-cell Adhesion Actin Filament Bundle Organization Actin Filament Bundle Assembly Structural Constituent Of Postsynapse Regulation Of Secretion By Cell Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Histone H3T6 Kinase Activity Ethanol Binding Negative Regulation Of Proteasomal Protein Catabolic Process Detection Of Peptidoglycan	Cytoplasm Cytosol Nucleoplasm Macromolecule Metabolic Process Nucleic Acid Metabolic Process Spliceosomal SnRNP Assembly Nucleus Cellular Component Assembly Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation Cajal Body Protein Binding Methylosome RNA Metabolic Process Transmembrane Transporter Binding Cytoskeleton Z Disc Pseudopodium Negative Regulation Of DNA Metabolic Process Cyclin E1-CDK2 Complex DNA End Binding Ku70:Ku80 Complex SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spliceosomal Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Postsynapse Telomere Maintenance POZ Domain Binding Nucleolus Main Axon DNA-dependent Protein Kinase Complex Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Regulation Of RNA Metabolic Process Macromolecule Methylation DNA-templated Transcription Identical Protein Binding Regulation Of Long-term Neuronal Synaptic Plasticity Protein Modification Process Platelet Alpha Granule Lumen Protein-containing Complex Assembly Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Telomeric DNA Binding Cellular Response To Gamma Radiation RNA Splicing Telomere Organization
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