PDLIM5 and GFI1B

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDLIM5	GFI1B
Description		PDZ and LIM domain 5	growth factor independent 1B transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Filamentous Actin Cell Projection Synapse Presynapse Postsynapse	Nucleus Nucleoplasm Transcription Regulator Complex Plasma Membrane Nuclear Matrix
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Actinin Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Muscle Structure Development Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hemopoiesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lewy body disease ( 25188341) Mean platelet volume ( 27863252 32888494) Myocardial infarction ( 33532862) PR interval ( 32439900) Prostate cancer ( 19767753) Pulse pressure ( 30578418) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Uterine fibroids ( 31649266) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 28552196)	Basophil percentage of white cells ( 27863252) Cardiometabolic and hematological traits ( 27668658) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		15 interacting genes: ACTB ACTN1 CACNA1B CCDC136 COIL DSCAM GFI1B KRT40 KRTAP10-7 NOD2 PRKCB PRKCE PRKCG TRIM39 ZYX	72 interacting genes: ACTN1 AGRN AJUBA ANKS3 ATXN2 BABAM2 BECN1 BEGAIN BEND5 BRCA1 CCDC136 CCDC85B CENPB COPS5 CPAP DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GPAT4 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 POLR1H PSMA3 RAB11FIP4 RCHY1 RCOR1 RINT1 RNF31 RUNDC3A TAF1 TLE5 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRF3
Entrez ID		10611	8328
HPRD ID		05799	05088
Ensembl ID		ENSG00000163110	ENSG00000165702
Uniprot IDs		A0A0A0MSP3 B7Z481 B7Z8X5 Q96HC4	A0A024R8F3 Q5VTD9
PDB IDs		2DAR 2UZC
Enriched GO Terms of Interacting Partners?		Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Cell Adhesion Synapse Regulation Of Neurotransmitter Secretion Response To Morphine Cell-cell Signaling Signaling Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Regulation Of Canonical NF-kappaB Signal Transduction Trans-synaptic Signaling Cell Communication Synaptic Signaling Positive Regulation Of Synaptic Transmission Presynaptic Cytosol Plasma Membrane Cell-cell Adhesion Cell-cell Junction Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Cytochalasin B Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Protein Ubiquitination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding ATP Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Brush Border Regulation Of Vesicle-mediated Transport Regulation Of Post-translational Protein Modification Cytoskeleton Cell Junction Assembly Regulation Of Norepinephrine Uptake Homotypic Cell-cell Adhesion Actin Filament Bundle Organization Actin Filament Bundle Assembly Structural Constituent Of Postsynapse Regulation Of Secretion By Cell Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Histone H3T6 Kinase Activity Ethanol Binding Negative Regulation Of Proteasomal Protein Catabolic Process Detection Of Peptidoglycan	Calcium Ion Binding Regulation Of Cell Communication Regulation Of Signaling Elastic Fiber Regulation Of Signal Transduction Extracellular Matrix Structural Constituent Elastic Fiber Assembly Transcription Coactivator Activity Integrin Binding Embryo Implantation Basement Membrane Auditory Receptor Cell Fate Commitment Protein Kinase C Binding Extracellular Matrix Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Assembly Regulation Of Growth Protein Binding Developmental Process Extracellular Matrix Assembly Nuclear Ubiquitin Ligase Complex Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic G2 DNA Damage Checkpoint Signaling Stress Fiber BRCA1-A Complex Cell-substrate Junction Assembly Protein Modification By Small Protein Conjugation Cell-substrate Junction Organization Negative Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Negative Regulation Of Wnt Signaling Pathway Cytoplasm Identical Protein Binding Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Population Proliferation Neuronal Ion Channel Clustering Astral Microtubule Organization Regulation Of Programmed Cell Death Protein Ubiquitination Vascular Associated Smooth Muscle Cell Development
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