PDLIM5

Description		PDZ and LIM domain 5
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Filamentous Actin Cell Projection Synapse Presynapse Postsynapse
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Actinin Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Heart Development Actin Cytoskeleton Organization Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Muscle Structure Development Cell-cell Adhesion
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lewy body disease ( 25188341) Mean platelet volume ( 27863252 32888494) Myocardial infarction ( 33532862) PR interval ( 32439900) Prostate cancer ( 19767753) Pulse pressure ( 30578418) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Uterine fibroids ( 31649266) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 28552196)
Novel Interacting Genes		1 novel interacting genes: PCDH7
Interacting Genes		15 interacting genes: ACTB ACTN1 CACNA1B CCDC136 COIL DSCAM GFI1B KRT40 KRTAP10-7 NOD2 PRKCB PRKCE PRKCG TRIM39 ZYX
Entrez ID		10611
HPRD ID		05799
Ensembl ID		ENSG00000163110
Uniprot IDs		A0A0A0MSP3 B7Z481 B7Z8X5 Q96HC4
PDB IDs		2DAR 2UZC
Enriched GO Terms of Interacting Partners?		Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Cell Adhesion Synapse Regulation Of Neurotransmitter Secretion Response To Morphine Cell-cell Signaling Signaling Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Regulation Of Canonical NF-kappaB Signal Transduction Trans-synaptic Signaling Cell Communication Synaptic Signaling Positive Regulation Of Synaptic Transmission Presynaptic Cytosol Plasma Membrane Cell-cell Adhesion Cell-cell Junction Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Cytochalasin B Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Protein Ubiquitination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding ATP Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Brush Border Regulation Of Vesicle-mediated Transport Regulation Of Post-translational Protein Modification Cytoskeleton Cell Junction Assembly Regulation Of Norepinephrine Uptake Homotypic Cell-cell Adhesion Actin Filament Bundle Organization Actin Filament Bundle Assembly Structural Constituent Of Postsynapse Regulation Of Secretion By Cell Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Histone H3T6 Kinase Activity Ethanol Binding Negative Regulation Of Proteasomal Protein Catabolic Process Detection Of Peptidoglycan
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