PDLIM5 and CACNA1B

Number of citations of the paper that reports this interaction (PubMedID 12665800)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PDLIM5	CACNA1B
Description		PDZ and LIM domain 5	calcium voltage-gated channel subunit alpha1 B
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Filamentous Actin Cell Projection Synapse Presynapse Postsynapse	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Actinin Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion	Nucleotide Binding Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Muscle Structure Development Cell-cell Adhesion	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Amyloid-beta
Pathways		Neurexins and neuroligins	Presynaptic depolarization and calcium channel opening
Drugs			Eptifibatide Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Nicardipine Verapamil Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Efonidipine Butamben Bioallethrin
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lewy body disease ( 25188341) Mean platelet volume ( 27863252 32888494) Myocardial infarction ( 33532862) PR interval ( 32439900) Prostate cancer ( 19767753) Pulse pressure ( 30578418) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Uterine fibroids ( 31649266) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 28552196)	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)
Interacting Genes		15 interacting genes: ACTB ACTN1 CACNA1B CCDC136 COIL DSCAM GFI1B KRT40 KRTAP10-7 NOD2 PRKCB PRKCE PRKCG TRIM39 ZYX	10 interacting genes: APBA1 CACNB3 CAMK2A GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		10611	774
HPRD ID		05799	03005
Ensembl ID		ENSG00000163110	ENSG00000148408
Uniprot IDs		A0A0A0MSP3 B7Z481 B7Z8X5 Q96HC4	Q00975
PDB IDs		2DAR 2UZC	2LCM 7MIX 7MIY 7VFS 7VFU 7VFV 7VFW
Enriched GO Terms of Interacting Partners?		Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Cell Adhesion Synapse Regulation Of Neurotransmitter Secretion Response To Morphine Cell-cell Signaling Signaling Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Regulation Of Canonical NF-kappaB Signal Transduction Trans-synaptic Signaling Cell Communication Synaptic Signaling Positive Regulation Of Synaptic Transmission Presynaptic Cytosol Plasma Membrane Cell-cell Adhesion Cell-cell Junction Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Cytochalasin B Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Protein Ubiquitination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding ATP Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Brush Border Regulation Of Vesicle-mediated Transport Regulation Of Post-translational Protein Modification Cytoskeleton Cell Junction Assembly Regulation Of Norepinephrine Uptake Homotypic Cell-cell Adhesion Actin Filament Bundle Organization Actin Filament Bundle Assembly Structural Constituent Of Postsynapse Regulation Of Secretion By Cell Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Histone H3T6 Kinase Activity Ethanol Binding Negative Regulation Of Proteasomal Protein Catabolic Process Detection Of Peptidoglycan	Synapse Modulation Of Chemical Synaptic Transmission G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Regulator Activity Heterotrimeric G-protein Complex Cytosol Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Transport Positive Regulation Of High Voltage-gated Calcium Channel Activity Peptidyl-threonine Autophosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Mu-type Opioid Receptor Binding Membrane Docking GTPase Activity Vesicle Docking Organelle Localization By Membrane Tethering Regulation Of Endocannabinoid Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cytoplasm Dendrite Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity N-terminal Protein Myristoylation Dendritic Spine Gamma-aminobutyric Acid Secretion Intracellular Protein Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Presynaptic Membrane Calmodulin-dependent Protein Phosphatase Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Acrosomal Vesicle Exocytosis Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Secretion By Cell Glutamate Receptor Binding Cell Projection Retinoic Acid-responsive Element Binding Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential
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