PLEKHA3 and TCL1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHA3	TCL1B
Description		pleckstrin homology domain containing A3	TCL1 family AKT coactivator B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Recycling Endosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi	Intracellular Signal Transduction
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)	Refractive error ( 32231278)
Interacting Genes		8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B	17 interacting genes: AKT1 AKT2 APP BAG4 DRC8 GLRX3 LSM1 LSM5 LSM7 MARK1 MEIS3 MKRN3 PLEKHA3 PNMA1 SNRPG TNPO2 ZNF330
Entrez ID		65977	9623
HPRD ID		09688	04795
Ensembl ID		ENSG00000116095	ENSG00000213231
Uniprot IDs		Q9HB20	O95988
PDB IDs		2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?			Lsm1-7-Pat1 Complex Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Ribonucleoprotein Complex Spliceosomal Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex U6 SnRNP RNA Splicing, Via Transesterification Reactions Negative Regulation Of PERK-mediated Unfolded Protein Response Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fibroblast Migration U2-type Prespliceosome Nucleus Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Polysaccharide Biosynthetic Process MRNA Catabolic Process Molecular Function Activator Activity U12-type Spliceosomal Complex Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Postsynapse Organization RNA Binding RNA Splicing Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Regulation Of Fatty Acid Oxidation Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Protein Localization To Plasma Membrane Regulation Of Fibroblast Migration Response To Nerve Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Glycogen Metabolic Process Cell Cortex Regulation Of TRNA Methylation
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