PLEKHA3 and RNMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHA3	RNMT
Description		pleckstrin homology domain containing A3	RNA guanine-7 methyltransferase
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GO Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Recycling Endosome	Fibrillar Center Nucleus Nucleoplasm MRNA Capping Enzyme Complex Receptor Complex MRNA Cap Methyltransferase RNMT:RAMAC Complex
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding	RNA Binding MRNA 5'-cap (guanine-N7-)-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi	7-methylguanosine MRNA Capping MRNA Processing Methylation RNA 5'-cap (guanine-N7)-methylation Cellular Response To Leukemia Inhibitory Factor
Pathways		Synthesis of PIPs at the plasma membrane	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)	Fractures ( 30158200)
Interacting Genes		8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B	5 interacting genes: EIF4E GMCL1 KPNA2 PLEKHA3 RNGTT
Entrez ID		65977	8731
HPRD ID		09688	04622
Ensembl ID		ENSG00000116095	ENSG00000101654
Uniprot IDs		Q9HB20	A8K946 K7EP06 O43148
PDB IDs		2KCJ 2MDX 3RCP	3BGV 3EPP 5E8J 5E9J 5E9W 8Q69 8Q8G 8Q9W
Enriched GO Terms of Interacting Partners?			Eukaryotic Initiation Factor 4G Binding MRNA Guanylyltransferase Activity MRNA 5'-triphosphate Monophosphatase Activity Inorganic Triphosphate Phosphatase Activity RNA Guanylyltransferase Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Polynucleotide 5'-phosphatase Activity MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Viral Penetration Into Host Nucleus Nuclear Transport Nucleocytoplasmic Transport Intracellular Transport Of Virus 7-methylguanosine MRNA Capping Host Cell Intracellular Transport NLS-dependent Protein Nuclear Import Complex RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Eukaryotic Translation Initiation Factor 4F Complex
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