USP16 and BTF3

		USP16	BTF3
Description		ubiquitin specific peptidase 16	basic transcription factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Cytosol Nascent Polypeptide-associated Complex
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	RNA Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division	In Utero Embryonic Development Protein Transport Negative Regulation Of Protein Localization To Endoplasmic Reticulum
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS			Eyebrow thickness ( 26926045) Monobrow thickness ( 26926045)
Interacting Genes		23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2	12 interacting genes: APP CDC42 CEBPA CSNK2B IFTAP MED21 NMT2 NOTO POLR2B TXLNA TXLNB ZDHHC17
Entrez ID		10600	689
HPRD ID		06881	03966
Ensembl ID		ENSG00000156256	ENSG00000145741
Uniprot IDs		Q9Y5T5	P20290
PDB IDs		2I50 8WG5	3LKX 3MCB 7QWQ 7QWR 9F1B 9F1C 9F1D 9FQ0
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Cell Projection Morphogenesis Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Amylin Binding Neuron Projection Morphogenesis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Peptide Positive Regulation Of Intracellular Signal Transduction Response To Cytokine Lipoprotein Particle Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of G Protein-coupled Receptor Internalization Macrophage Differentiation Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Ribonucleoside Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity Prostaglandin-I Synthase Activity Glycylpeptide N-tetradecanoyltransferase Activity Protein Lipidation N-terminal Peptidyl-glycine N-myristoylation Peptidyl-lysine N6-myristoyltransferase Activity Positive Regulation Of Ribosome Biogenesis
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