SMC2 and TRAF3IP1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		SMC2	TRAF3IP1
Description		structural maintenance of chromosomes 2	TRAF3 interacting protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Extracellular Exosome	Fibrillar Center Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Axoneme Nuclear Body Intraciliary Transport Particle B Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity	Protein Binding Microtubule Binding
	Biological Process	Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Morphogenesis Of A Polarized Epithelium Kidney Development Negative Regulation Of Protein Phosphorylation Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Intraciliary Anterograde Transport Post-anal Tail Morphogenesis Intraciliary Transport Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Animal Organ Development System Development Negative Regulation Of Defense Response To Virus Defense Response To Virus Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203 33549134) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)	Chronotype ( 30696823) FEV1 ( 30804560) Intraocular pressure ( 29617998 29785010 30054594) Iris characteristics ( 21835309) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Morning person ( 30696823) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: ABCC5 CDC42 CEBPA DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 TRAF3IP1	31 interacting genes: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT ITSN1 MACF1 OLFM1 PCNT SFR1 SGF29 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 UBXN10 WAC
Entrez ID		10592	26146
HPRD ID		09277	09571
Ensembl ID		ENSG00000136824	ENSG00000204104
Uniprot IDs		A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	Q8TDR0
PDB IDs		4U4P	2EQO 8KCQ
Enriched GO Terms of Interacting Partners?		Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Organelle Organization Dendritic Spine Morphogenesis Response To Lithium Ion Cellular Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Organization Mitotic Chromosome Condensation Regulation Of Chromosome Condensation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Embryonic Heart Tube Development Phagocytosis, Engulfment Positive Regulation Of Chromosome Segregation Dendritic Spine Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Separation Condensed Chromosome Positive Regulation Of Organelle Organization Response To Electrical Stimulus Chromosome Condensation Positive Regulation Of Proteolysis Neuron Projection Organization Postsynapse Organization System Development Regulation Of Cell-substrate Adhesion Ciliary Base Macrophage Differentiation Membrane Invagination Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency Regulation Of Chromosome Organization Negative Regulation Of Synaptic Vesicle Clustering Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Process Mononuclear Cell Differentiation GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Cycle	Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Postsynapse Organization Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Axo-dendritic Transport Regulation Of Axon Extension Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Golgi To Plasma Membrane Protein Transport Cytoskeleton Organization Positive Regulation Of Axon Extension Meiotic Chromosome Condensation Establishment Of Protein Localization Condensin Complex Positive Regulation Of Chromosome Condensation Cilium Assembly Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Golgi Vesicle Transport Regulation Of Dendritic Spine Development Dendritic Spine Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Cilium Organization CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Axon Cytoplasm Axonal Transport Cellular Localization Organelle Assembly Regulation Of Developmental Growth Transport Along Microtubule Clathrin-coated Pit MyD88-independent Toll-like Receptor Signaling Pathway Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Endosome Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Developmental Process Plasma Membrane Bounded Cell Projection Assembly Signaling Adaptor Activity Mitotic Chromosome Condensation
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