SMC2 and NCAPD2

Number of citations of the paper that reports this interaction (PMID 10958694)
34

Data Source:
HPRD (in vivo)

		SMC2	NCAPD2
Gene Name		structural maintenance of chromosomes 2	non-SMC condensin I complex, subunit D2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Nuclear Chromosome Condensed Chromosome Condensin Complex Condensin Core Heterodimer Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Pronucleus
	Molecular Function	Protein Binding ATP Binding Protein Heterodimerization Activity	Protein Binding Histone Binding
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization	Mitotic Cell Cycle Mitotic Chromosome Condensation Cell Division
Pathways		Mitotic Prometaphase Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes	Mitotic Prometaphase Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Orofacial clefts (interaction) ( 21618603)
Protein-Protein Interactions		8 interactors: ABCC5 DISC1 DNMT3B GULP1 LIG4 NCAPD2 SMC4 TRAF3IP1	5 interactors: CDK1 CSNK2A1 NCAPH SMC2 SMC4
Entrez ID		10592	9918
HPRD ID		09277	06472
Ensembl ID		ENSG00000136824	ENSG00000010292
Uniprot IDs		A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	B3KMS0 B3KY03 F5GZJ1 Q15021
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Chromosome Condensation Chromosome Condensation Organelle Organization Chromosome Organization DNA Metabolic Process Positive Regulation Of Neurogenesis Mitotic Sister Chromatid Segregation Cell Division DNA Ligation Involved In DNA Recombination Sister Chromatid Segregation Positive Regulation Of Cell Development S-adenosylmethioninamine Metabolic Process Response To Ionizing Radiation Regulation Of Neurogenesis Meiotic Chromosome Condensation DNA Methylation On Cytosine Within A CG Sequence DNA Packaging C-5 Methylation Of Cytosine Lagging Strand Elongation Pro-B Cell Differentiation S-adenosylhomocysteine Metabolic Process Regulation Of Cell Development Positive Regulation Of Cell Differentiation Chromosome Segregation Methylation-dependent Chromatin Silencing Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Hyaluronan Biosynthetic Process DNA Ligation Involved In DNA Repair DNA Conformation Change Lymphoid Progenitor Cell Differentiation Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Nervous System Development Phagocytosis, Engulfment Mitotic Nuclear Division Negative Regulation Of Interferon-beta Production DNA Ligation Positive Regulation Of Histone H3-K4 Methylation Nucleotide-excision Repair, DNA Gap Filling Mitochondrial Calcium Ion Homeostasis Cellular Response To Lithium Ion Membrane Invagination Protein Complex Localization Negative Regulation Of Histone Methylation Regulation Of Synapse Maturation Post-anal Tail Morphogenesis	Chromosome Condensation Mitotic Chromosome Condensation DNA Packaging Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Conformation Change Meiotic Chromosome Condensation Mitotic Nuclear Division Cell Cycle Process Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Division Cell Cycle Chromosome Segregation Kinetochore Organization Chromosome Organization DNA Metabolic Process Meiotic Chromosome Segregation Pronuclear Fusion Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division Nitrogen Compound Metabolic Process Meiotic Cell Cycle Reproduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Cycle Checkpoint Regulation Of Schwann Cell Differentiation Organelle Organization Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis
Tagcloud ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase	aberration birc5 bub1 candidates cysts datasets defining driver dysregulated epcam epithelium estrous fallopian hormones inclusion list nuak2 ovarian ovulation ovulations ovulatory prioritised proestrus publically represented segregation serous silico tube
Tagcloud (Difference) ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase	aberration birc5 bub1 candidates cysts datasets defining driver dysregulated epcam epithelium estrous fallopian hormones inclusion list nuak2 ovarian ovulation ovulations ovulatory prioritised proestrus publically represented segregation serous silico tube
Tagcloud (Intersection) ?