SMC2 and SMC4

Number of citations of the paper that reports this interaction (PMID 9789013)
28

Data Source:
HPRD (in vitro, in vivo)

		SMC2	SMC4
Gene Name		structural maintenance of chromosomes 2	structural maintenance of chromosomes 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Condensin Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Protein Heterodimerization Activity	Protein Binding ATP Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization
Pathways		Mitotic Prometaphase Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes	Mitotic Prometaphase Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Orofacial clefts (interaction) ( 21618603)
Protein-Protein Interactions		8 interactors: ABCC5 DISC1 DNMT3B GULP1 LIG4 NCAPD2 SMC4 TRAF3IP1	3 interactors: NCAPD2 SMC2 TRAF3IP1
Entrez ID		10592	10051
HPRD ID		09277	09276
Ensembl ID		ENSG00000136824	ENSG00000113810
Uniprot IDs		A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	E9PD53 Q9NTJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Chromosome Condensation Chromosome Condensation Organelle Organization Chromosome Organization DNA Metabolic Process Positive Regulation Of Neurogenesis Mitotic Sister Chromatid Segregation Cell Division DNA Ligation Involved In DNA Recombination Sister Chromatid Segregation Positive Regulation Of Cell Development S-adenosylmethioninamine Metabolic Process Response To Ionizing Radiation Regulation Of Neurogenesis Meiotic Chromosome Condensation DNA Methylation On Cytosine Within A CG Sequence DNA Packaging C-5 Methylation Of Cytosine Lagging Strand Elongation Pro-B Cell Differentiation S-adenosylhomocysteine Metabolic Process Regulation Of Cell Development Positive Regulation Of Cell Differentiation Chromosome Segregation Methylation-dependent Chromatin Silencing Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Hyaluronan Biosynthetic Process DNA Ligation Involved In DNA Repair DNA Conformation Change Lymphoid Progenitor Cell Differentiation Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Nervous System Development Phagocytosis, Engulfment Mitotic Nuclear Division Negative Regulation Of Interferon-beta Production DNA Ligation Positive Regulation Of Histone H3-K4 Methylation Nucleotide-excision Repair, DNA Gap Filling Mitochondrial Calcium Ion Homeostasis Cellular Response To Lithium Ion Membrane Invagination Protein Complex Localization Negative Regulation Of Histone Methylation Regulation Of Synapse Maturation Post-anal Tail Morphogenesis	Mitotic Chromosome Condensation Chromosome Condensation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation DNA Packaging Chromosome Segregation DNA Conformation Change Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Division Meiotic Chromosome Condensation Negative Regulation Of Interferon-beta Production Mitotic Cell Cycle Process Organelle Organization Post-anal Tail Morphogenesis Mitotic Cell Cycle Negative Regulation Of Defense Response To Virus Kinetochore Organization Negative Regulation Of Embryonic Development Negative Regulation Of Smoothened Signaling Pathway Intraciliary Transport Regulation Of Interferon-beta Production Chromosome Organization Cell Cycle Process Negative Regulation Of Type I Interferon Production DNA Metabolic Process Embryonic Camera-type Eye Development Neural Tube Patterning Embryonic Digit Morphogenesis Cell Cycle Meiotic Chromosome Segregation Regulation Of Defense Response To Virus Embryonic Heart Tube Development Regulation Of Smoothened Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Embryonic Development Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport
Tagcloud ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase	affymetrix annotations apdf aurka bicarbonate blpdf bpdf buffered ccnb1 ccne2 cdk1 containingpdf cpdf diamond diluted genechip icodextrin insufficiently ipdf kif11 kif14 lpdf mesothelial omentum pdf pmc repressors u133plus2 uremic
Tagcloud (Difference) ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase	affymetrix annotations apdf aurka bicarbonate blpdf bpdf buffered ccnb1 ccne2 cdk1 containingpdf cpdf diamond diluted genechip icodextrin insufficiently ipdf kif11 kif14 lpdf mesothelial omentum pdf pmc repressors u133plus2 uremic
Tagcloud (Intersection) ?