SMC2

Description		structural maintenance of chromosomes 2
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GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203 33549134) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)
Novel Interacting Genes		1 novel interacting genes: ERP44
Interacting Genes		11 interacting genes: ABCC5 CDC42 CEBPA DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 TRAF3IP1
Entrez ID		10592
HPRD ID		09277
Ensembl ID		ENSG00000136824
Uniprot IDs		A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1
PDB IDs		4U4P
Enriched GO Terms of Interacting Partners?		Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Organelle Organization Dendritic Spine Morphogenesis Response To Lithium Ion Cellular Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Organization Mitotic Chromosome Condensation Regulation Of Chromosome Condensation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Embryonic Heart Tube Development Phagocytosis, Engulfment Positive Regulation Of Chromosome Segregation Dendritic Spine Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Separation Condensed Chromosome Positive Regulation Of Organelle Organization Response To Electrical Stimulus Chromosome Condensation Positive Regulation Of Proteolysis Neuron Projection Organization Postsynapse Organization System Development Regulation Of Cell-substrate Adhesion Ciliary Base Macrophage Differentiation Membrane Invagination Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency Regulation Of Chromosome Organization Negative Regulation Of Synaptic Vesicle Clustering Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Process Mononuclear Cell Differentiation GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Cycle
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