SCGN and SNAP23

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SCGN	SNAP23
Description		secretagogin, EF-hand calcium binding protein	synaptosome associated protein 23
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Membrane Dendrite Transport Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Adherens Junction Focal Adhesion Cilium Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Specific Granule Membrane Specific Granule Azurophil Granule Neuron Projection Synapse Extracellular Exosome Tertiary Granule Membrane Presynapse
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process		Histamine Secretion By Mast Cell Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Targeting Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Fusion
Pathways			ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Feeling guilty ( 29500382) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Intrinsic epigenetic age acceleration ( 29374233) Iron status biomarkers ( 19084217) Iron status biomarkers (iron levels) ( 28334935) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Liver iron content ( 34128465) Lung cancer in ever smokers ( 28604730) Oily fish consumption ( 32066663) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Plateletcrit ( 32888494) Pork consumption ( 32066663) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Uric acid levels ( 19503597) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 31043756)
Interacting Genes		7 interacting genes: ARFGAP2 ATP5F1A DDAH2 KIF5B MLF2 SNAP23 TUBB3	32 interacting genes: ABI2 ABI3 CFTR FXR2 ITSN1 KIF5B MATR3 NAPA NAPB PRKCA SCAMP1 SCAMP2 SCGN SNAPIN SNTG1 STX11 STX12 STX1A STX1B STX3 STX4 STX5 STX6 STXBP2 STXBP5 TLK1 VAMP1 VAMP2 VAMP3 VAMP7 VAMP8 WASH2P
Entrez ID		10590	8773
HPRD ID		10211	03962
Ensembl ID		ENSG00000079689	ENSG00000092531
Uniprot IDs		O76038	A8K287 O00161
PDB IDs		8BAV	1NHL 3ZUS
Enriched GO Terms of Interacting Partners?		Mitochondrion Adenyl Ribonucleotide Binding Proton-transporting Two-sector ATPase Complex Angiostatin Binding Stress Granule Disassembly Anterograde Neuronal Dense Core Vesicle Transport Ciliary Rootlet Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Cytoplasm Organization Neuron Projection Guidance Cytolytic Granule Membrane Retrograde Neuronal Dense Core Vesicle Transport Anterograde Axonal Protein Transport Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Axon Guidance Plus-end-directed Organelle Transport Along Microtubule Mitocytosis Dense Core Granule Cytoskeletal Transport Histamine Secretion By Mast Cell Histamine Transport Histamine Secretion Netrin-activated Signaling Pathway Netrin Receptor Binding Dorsal Root Ganglion Development Citrulline Metabolic Process Dimethylargininase Activity COPI Coating Of Golgi Vesicle Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Anterograde Dendritic Transport Azurophil Granule Vesicle Fusion To Plasma Membrane	SNARE Complex SNAP Receptor Activity Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Organelle Fusion SNARE Binding Exocytosis Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Protein Transport Establishment Of Protein Localization Vesicle-mediated Transport Secretion By Cell Vesicle Organization Secretion Membrane Organization Establishment Of Localization In Cell Intracellular Protein Localization SNARE Complex Assembly Syntaxin Binding Organelle Localization Intracellular Protein Transport Regulation Of Exocytosis Cellular Localization Intracellular Transport Regulation Of Synaptic Vesicle Priming Regulation Of Vesicle-mediated Transport Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Secretion By Cell Regulated Exocytosis Calcium-ion Regulated Exocytosis Endomembrane System Regulation Of Secretion Zymogen Granule Membrane Phagocytic Vesicle Positive Regulation Of Exocytosis Neutrophil Degranulation Regulation Of Histamine Secretion By Mast Cell Vesicle-mediated Transport In Synapse Neuron Projection Recycling Endosome Membrane Secretory Granule Regulation Of Hormone Secretion Golgi Vesicle Transport Positive Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Synaptic Vesicle Exocytosis Synaptic Vesicle Membrane
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