SCGN and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SCGN	DDAH2
Description		secretagogin, EF-hand calcium binding protein	DDAH family member 2, ADMA-independent
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Membrane Dendrite Transport Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse	Cytoplasm Mitochondrion Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding Dimethylargininase Activity Hydrolase Activity
	Biological Process		Citrulline Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process
Pathways
Drugs			Citrulline
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Feeling guilty ( 29500382) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Intrinsic epigenetic age acceleration ( 29374233) Iron status biomarkers ( 19084217) Iron status biomarkers (iron levels) ( 28334935) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Liver iron content ( 34128465) Lung cancer in ever smokers ( 28604730) Oily fish consumption ( 32066663) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Plateletcrit ( 32888494) Pork consumption ( 32066663) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Uric acid levels ( 19503597) Waist circumference adjusted for body mass index ( 34021172)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: ARFGAP2 ATP5F1A DDAH2 KIF5B MLF2 SNAP23 TUBB3	28 interacting genes: ACTN3 ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 FANCL GADD45G IGFN1 MAP3K20 MKNK1 NOXA1 PIN1 PRKAB2 RAP1B RCC1 RPS6KA1 RPS6KA5 SCGN SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		10590	23564
HPRD ID		10211	09204
Ensembl ID		ENSG00000079689	ENSG00000213722
Uniprot IDs		O76038	O95865 V9HW53
PDB IDs		8BAV
Enriched GO Terms of Interacting Partners?		Mitochondrion Adenyl Ribonucleotide Binding Proton-transporting Two-sector ATPase Complex Angiostatin Binding Stress Granule Disassembly Anterograde Neuronal Dense Core Vesicle Transport Ciliary Rootlet Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Cytoplasm Organization Neuron Projection Guidance Cytolytic Granule Membrane Retrograde Neuronal Dense Core Vesicle Transport Anterograde Axonal Protein Transport Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Axon Guidance Plus-end-directed Organelle Transport Along Microtubule Mitocytosis Dense Core Granule Cytoskeletal Transport Histamine Secretion By Mast Cell Histamine Transport Histamine Secretion Netrin-activated Signaling Pathway Netrin Receptor Binding Dorsal Root Ganglion Development Citrulline Metabolic Process Dimethylargininase Activity COPI Coating Of Golgi Vesicle Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Anterograde Dendritic Transport Azurophil Granule Vesicle Fusion To Plasma Membrane	Cytoplasm Nucleus Regulation Of Mitotic Cell Cycle Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Cytosol Regulation Of Cell Cycle Process Protein Kinase Activity JNK Cascade Response To Phorbol 13-acetate 12-myristate Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Epithelial Cell Proliferation Cellular Response To UV-B Protein Phosphorylation Identical Protein Binding Intracellular Signaling Cassette Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Phosphorylation Magnesium Ion Binding Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Phase Transition Regulation Of Translation In Response To Stress Positive Regulation Of JNK Cascade Response To UV-B Regulation Of Cell Cycle Phase Transition Cellular Response To Gamma Radiation Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process Protein Binding Z Disc Phosphate-containing Compound Metabolic Process Signal Transduction Nucleotide Binding ATP Binding Cyclin Binding Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Nuclear Division Cis-trans Isomerase Activity Positive Regulation Of Apoptotic Process Histone H2AS1 Kinase Activity Positive Regulation Of Mitotic DNA Damage Checkpoint
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