FKBP2 and EPB41L2

Number of citations of the paper that reports this interaction (PubMedID 9531554)
58

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		FKBP2	EPB41L2
Description		FKBP prolyl isomerase 2	erythrocyte membrane protein band 4.1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Spectrin COP9 Signalosome Membrane Cell Junction Extracellular Exosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity	Actin Binding Structural Molecule Activity Protein Binding Cytoskeletal Protein Binding Spectrin Binding PH Domain Binding
	Biological Process		Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Positive Regulation Of Protein Localization To Cell Cortex
Pathways			Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 34002096) Crohn's disease ( 28067908) Fruit consumption ( 32066663)	Appendicular lean mass ( 33097823) Cerebellum white matter volume ( 31530798) Colorectal cancer (calcium intake interaction) ( 25192705) Creativity ( 32133506) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lentiform nucleus volume ( 22903471) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pars triangularis volume ( 31530798) Plateletcrit ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Interacting Genes		14 interacting genes: ARFGEF1 BAG6 BARD1 C1QC EPB41 EPB41L2 MAPK3 RAB3C RAB6A RAP2A UBQLN1 UBQLN2 UBQLN4 VAMP2	17 interacting genes: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 GRM1 HMGA1 HSPB1 NUMA1 PARP1 RNF10 SPTAN1 VIM YWHAH
Entrez ID		2286	2037
HPRD ID		01742	09126
Ensembl ID		ENSG00000173486	ENSG00000079819
Uniprot IDs		A0A494C1N0 P26885 Q53XJ5	A0A994J5B1 B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 Q59FD8
PDB IDs		2PBC 4NNR
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway Regulation Of Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Proteolysis Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Cell Cortex Autophagosome Organelle Organization Autophagosome Assembly Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Catabolic Process Myosin V Binding Autophagosome Organization Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Cytosol Regulation Of Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Spectrin Binding Regulation Of Autophagy Perinuclear Region Of Cytoplasm Cortical Actin Cytoskeleton Organization Negative Regulation Of Transport Vacuole Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization Trans-Golgi Network Cytoplasmic Vesicle Exocytosis Positive Regulation Of Proteolysis Cortical Cytoskeleton Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MRNA 3'-end Processing Peptidyl-cysteine Methylation Negative Regulation Of Store-operated Calcium Channel Activity Response To Endoplasmic Reticulum Stress Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process	Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Synaptic Transmission Dendrite Modulation Of Chemical Synaptic Transmission Cognition Learning Long-term Synaptic Depression Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Neurotransmitter Uptake Cell Body Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Associative Learning Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Learning Or Memory Memory Positive Regulation Of Synaptic Transmission Regulation Of System Process Nervous System Process Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Chemical Synaptic Transmission Response To Cocaine Dopamine Neurotransmitter Receptor Activity Dendritic Spine Cell-cell Signaling Synapse Regulation Of Metal Ion Transport Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Heterotrimeric G-protein Binding Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Visual Learning Signaling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cell Communication Visual Behavior System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Locomotory Behavior Glial Cell Development Regulation Of Biological Quality Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Behavior Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Amine Transport
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