TRIM50

Description		tripartite motif containing 50
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Innate Immune Response
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		39 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620
Entrez ID		135892
HPRD ID		15566
Ensembl ID		ENSG00000146755
Uniprot IDs		B7ZLG2 Q86XT4
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein K63-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Catabolic Process TORC1 Signaling ISG15 Transferase Activity TOR Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Nucleotide Binding ISG15-protein Conjugation Protein Binding Ubiquitin Protein Ligase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Protein Destabilization Radial Spoke Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Collateral Sprouting ERBB Signaling Pathway Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Metabolic Process
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