TACC3 and CDH1

Number of citations of the paper that reports this interaction (PMID 19823035)
5

Data Source:
BioGRID (two hybrid)

		TACC3	CDH1
Gene Name		transforming, acidic coiled-coil containing protein 3	cadherin 1, type 1, E-cadherin (epithelial)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Aggresome Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Node Of Ranvier Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Axon Terminus Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Domain Specific Binding Ankyrin Binding GTPase Activating Protein Binding Gamma-catenin Binding Cell Adhesion Molecule Binding
	Biological Process	Microtubule Cytoskeleton Organization Response To Hypoxia Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Hemopoiesis Astral Microtubule Organization Regulation Of Microtubule-based Process Cytoplasmic Sequestering Of Transcription Factor Regulation Of Cell Cycle	Trophectodermal Cell Differentiation Epithelial Cell Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Sensory Perception Of Sound Response To Toxic Substance Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Metabolic Process Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neuron Projection Development Regulation Of Water Loss Via Skin Cell Junction Assembly Adherens Junction Organization Response To Drug Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Regulation Of Immune Response Protein Homooligomerization Intestinal Epithelial Cell Development Salivary Gland Cavitation Regulation Of Branching Involved In Salivary Gland Morphogenesis Tight Junction Assembly Cellular Response To Amino Acid Stimulus Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Development Regulation Of Protein Localization To Cell Surface Regulation Of Neuron Migration
Pathways			Cell junction organization Apoptotic cleavage of cellular proteins Adherens junctions interactions Apoptotic execution phase Degradation of the extracellular matrix Apoptotic cleavage of cell adhesion proteins Cell-cell junction organization Programmed Cell Death Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)	Colorectal cancer ( 19011631) Ulcerative colitis ( 19915572)
Protein-Protein Interactions		13 interactors: AKAP9 ARNT2 ASPSCR1 AURKA CDH1 CIB3 KAT2A KIZ NDEL1 SNX20 TBC1D22B TTF2 VPS37C	55 interactors: ACTR3 ANAPC1 ANAPC11 ANAPC4 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC16 CDC23 CDC26 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBB2IP EZR FER FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP MAD2L2 MDM2 NDRG1 NEDD9 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 TACC3 UCHL3 VCL YES1
Entrez ID		10460	999
HPRD ID		05601	01885
Ensembl ID		ENSG00000013810	ENSG00000039068
Uniprot IDs		Q9Y6A5	P12830 Q9UII8
PDB IDs			1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Mitotic Centrosome Separation Centrosome Separation Positive Regulation Of Metabolic Process Centrosome Localization In Utero Embryonic Development Cell Cycle Process Embryo Development Mitotic Cell Cycle Process Centrosome Cycle Cell Cycle Neuron Projection Extension Mitotic Cell Cycle Brain Development Mitotic Nuclear Division Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Head Development Negative Regulation Of Spindle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Membrane Organization Developmental Cell Growth Positive Regulation Of Cellular Metabolic Process Centrosome Organization Spindle Assembly Involved In Female Meiosis I Pharynx Development Central Nervous System Development Blastocyst Development Microtubule Cytoskeleton Organization Forebrain Development Microtubule Organizing Center Organization Spindle Assembly Involved In Meiosis Epithelium Development Growth Protein Localization G2/M Transition Of Mitotic Cell Cycle Spindle Organization System Development Organ Development Spindle Stabilization Developmental Growth Involved In Morphogenesis Regulation Of Protein Stability Digestive Tract Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Growth Organelle Organization Cellular Response To Indole-3-methanol Histone H3-K14 Acetylation Positive Regulation Of Cellular Protein Catabolic Process Digestive System Development Positive Regulation Of Axon Regeneration	Single Organismal Cell-cell Adhesion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Adhesion Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Anatomical Structure Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Proteolysis Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Catabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?