ZRANB1 and RAPGEF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZRANB1	RAPGEF3
Description		zinc finger RANBP2-type containing 1	Rap guanine nucleotide exchange factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Deubiquitinase Activity	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding
	Biological Process	Autophagosome Assembly Proteolysis Cytoskeleton Organization Wnt Signaling Pathway Cell Migration Protein Deubiquitination Regulation Of Cell Morphogenesis Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Phosphatidylinositol Phosphate Biosynthetic Process Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Deubiquitination	Angiogenesis Adaptive Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Associative Learning Rap Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP
Pathways		Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases	Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Creatine kinase levels ( 29403010) Height ( 25429064 31562340) Lung cancer ( 34062886)	A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		130 interacting genes: AKT1 ARHGEF5 ARRDC2 ARRDC3 ATOSB BAHD1 BRD1 C1orf35 CARD9 CBX7 CBX8 CCDC120 CCDC13 CCDC185 CCDC187 CCHCR1 CCNL1 CDC45 CDK18 CDKL3 CNNM3 CORO7 CPNE7 CWF19L2 DCX DNAJB13 DTNB DUSP13B ENKD1 FAIM FAM124B FAM161A FAM161B FAM50B FAM90A1 FNDC11 GADD45GIP1 GAS2L2 GEM GLIS2 GPANK1 HOXB5 HOXC8 IL16 INO80B IP6K3 IQUB JRK KANK2 KIF9 KIFC3 LENG1 LMO3 LNX1 MAGEB4 MAGOH MCRS1 METTL21A MID2 MPPED1 MYEF2 NEK6 NUDT16L1 PHF1 PHF19 PKN1 PLEKHN1 PNMA5 POLDIP3 POLL PPP1R18 PSPC1 RAPGEF3 RASAL3 SCNM1 SDCBP SLC7A11 SNCA STAMBPL1 SUV39H1 SYT17 SYTL4 TBC1D3 TBC1D30 TBC1D3B TBC1D3C TBC1D3G TBC1D3K TCEANC THAP7 TIE1 TLE5 TNS4 TRAF3IP3 TRAF4 TRAF6 TRAPPC2 TRAPPC2B TSGA10IP TSPYL4 TSTD2 TTC23 TWIST1 UBASH3A UBC UBE2D1 UBE2G1 USP2 UVRAG VAV3 WT1 ZBTB24 ZBTB47 ZNF124 ZNF17 ZNF250 ZNF408 ZNF417 ZNF438 ZNF490 ZNF497 ZNF552 ZNF575 ZNF587 ZNF599 ZNF648 ZNF764 ZNF775 ZNF792 ZNF837	14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1
Entrez ID		54764	10411
HPRD ID		11738	06928
Ensembl ID		ENSG00000019995	ENSG00000079337
Uniprot IDs		Q9UGI0	O95398 Q99777
PDB IDs		3ZRH 5AF6	6H7E
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Zinc Ion Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Nuclear Speck Regulation Of Macromolecule Metabolic Process Microtubule Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process	Clathrin Adaptor Complex GDP Binding Rap Protein Signal Transduction Clathrin Adaptor Activity Response To Hydroperoxide GTP Binding Hydrolase Activity Intracellular Protein Localization Establishment Of Protein Localization Regulation Of Protein Localization To Membrane Regulation Of Response To Tumor Cell DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Liver Regeneration Regulation Of Collagen Metabolic Process Response To Ketone Regulation Of Collagen Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Viral RNA Genome Packaging Retrograde Axonal Protein Transport Primary Dendrite Response To Antineoplastic Agent Small GTPase-mediated Signal Transduction Animal Organ Regeneration G Protein Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Wortmannin Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Purine Nucleoside Binding DeUFMylase Activity
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