MIR206 and SF3B3

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR206	SF3B3
Description		microRNA 206	splicing factor 3b subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex	SAGA Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	MRNA 3'-UTR Binding Protein Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding Protein Binding U2 SnRNA Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cholesterol Efflux Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Formation	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Regulation Of DNA Repair MRNA Processing RNA Splicing Negative Regulation Of Protein Catabolic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription U2-type Prespliceosome Assembly
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs			Quercetin
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061)
Interacting Genes		78 interacting genes: ADARB1 AIMP1 AQR C1QBP CELF1 CPSF1 CSTF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LCORL LIN28A LIN28B LRPPRC MARS1 MATR3 NOL4L NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346	108 interacting genes: APBB1 EFTUD2 EIF4ENIF1 EPS8 ERCC6 ERG HCK HGS HSPB1 KIF13B KLF10 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPP3 NAGK NOL12 OSGEP PPIL1 PRKN PRPF40A RAD9A RBFOX2 RBM6 RNF10 RUFY2 SF3B1 SMAD5 SNRNP200 SREK1 TAF9 TCERG1 TOE1 U2AF2 USP7 WBP4 WWOX YWHAG ZNF579
Entrez ID		406989	23450
HPRD ID			12027
Ensembl ID		ENSG00000207604	ENSG00000189091
Uniprot IDs			A8K6V3 Q15393
PDB IDs			5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6AHD 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7KTS 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8H7G 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Gene Expression Nucleolus Positive Regulation Of Cytoplasmic Translation Regulation Of Macromolecule Biosynthetic Process Ligase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process RNA Destabilization Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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