MIR206 and PLOD1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR206	PLOD1
Description		microRNA 206	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	RISC Complex	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Rough Endoplasmic Reticulum Membrane Extracellular Matrix Extracellular Exosome Catalytic Complex
	Molecular Function	MRNA 3'-UTR Binding Protein Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cholesterol Efflux Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Formation	Response To Hypoxia Protein O-linked Glycosylation Epidermis Development Peptidyl-lysine Hydroxylation Collagen Fibril Organization
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid
Diseases			Nevo syndrome Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS			Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Moyamoya disease ( 29273593) Platelet count ( 27863252) Plateletcrit ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		78 interacting genes: ADARB1 AIMP1 AQR C1QBP CELF1 CPSF1 CSTF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LCORL LIN28A LIN28B LRPPRC MARS1 MATR3 NOL4L NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346	41 interacting genes: MIR1-2 MIR10B MIR122 MIR128-2 MIR141 MIR143 MIR15A MIR15B MIR17 MIR18A MIR18B MIR199A2 MIR19A MIR19B1 MIR206 MIR20A MIR214 MIR221 MIR222 MIR29B1 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PDE4B USP4
Entrez ID		406989	5351
HPRD ID			01086
Ensembl ID		ENSG00000207604	ENSG00000083444
Uniprot IDs			Q02809
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Gene Expression Nucleolus Positive Regulation Of Cytoplasmic Translation Regulation Of Macromolecule Biosynthetic Process Ligase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of MRNA Stability Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Extracellular Space Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Vasculature Development Negative Regulation Of Extracellular Matrix Assembly Positive Regulation Of Tissue Remodeling Negative Regulation Of Sprouting Angiogenesis
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