MRVI1 and ITPR1

Number of citations of the paper that reports this interaction (PMID 10724174)
66

Data Source:
HPRD (in vivo)

		MRVI1	ITPR1
Gene Name		murine retrovirus integration site 1 homolog	inositol 1,4,5-trisphosphate receptor, type 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane
	Molecular Function	Protein Binding	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding
	Biological Process	Blood Coagulation CGMP-mediated Signaling Relaxation Of Vascular Smooth Muscle	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase cGMP effects	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Platelet aggregation ( 20526338)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: ITPR1 PRKG1	29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		10335	3708
HPRD ID		05242	00925
Ensembl ID		ENSG00000072952	ENSG00000150995
Uniprot IDs		Q9Y6F6	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners?		Second-messenger-mediated Signaling Voluntary Musculoskeletal Movement Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Calcium-mediated Signaling Relaxation Of Vascular Smooth Muscle CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Response To Wounding Negative Regulation Of Smooth Muscle Contraction Regulation Of Platelet Aggregation Inositol Phosphate-mediated Signaling Negative Regulation Of Platelet Activation Negative Regulation Of Muscle Contraction Relaxation Of Muscle Cyclic-nucleotide-mediated Signaling Regulation Of Platelet Activation Vasodilation Endoplasmic Reticulum Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Sequestering Of Calcium Ion Regulation Of Calcium-mediated Signaling Musculoskeletal Movement Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Regulation Of Smooth Muscle Contraction Negative Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C Activity Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Vessel Size Regulation Of Tube Size Intracellular Signal Transduction Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Catalytic Activity Regulation Of Wound Healing Negative Regulation Of Cell-cell Adhesion Energy Reserve Metabolic Process Post-embryonic Development Dendrite Development	Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		abl attributable ba bcr chromosomal col5a1 cxcl10 dok2 f3 fusions gbp1 gp49b id1 imatinib involve isg20 leukemogenesis microarray offers oligonucleotide overlapping pdgfrb scinderin stat1 switched tel translocations uniquely valpha1	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		abl attributable ba bcr chromosomal col5a1 cxcl10 dok2 f3 fusions gbp1 gp49b id1 imatinib involve isg20 leukemogenesis microarray offers oligonucleotide overlapping pdgfrb scinderin stat1 switched tel translocations uniquely valpha1	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?