MRVI1 and PRKG1

Number of citations of the paper that reports this interaction (PMID 10724174)
66

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		MRVI1	PRKG1
Gene Name		murine retrovirus integration site 1 homolog	protein kinase, cGMP-dependent, type I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protein Binding	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Blood Coagulation CGMP-mediated Signaling Relaxation Of Vascular Smooth Muscle	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase cGMP effects	Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Platelet aggregation ( 20526338)	Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: ITPR1 PRKG1	34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646
Entrez ID		10335	5592
HPRD ID		05242	08910
Ensembl ID		ENSG00000072952	ENSG00000185532
Uniprot IDs		Q9Y6F6	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Second-messenger-mediated Signaling Voluntary Musculoskeletal Movement Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Calcium-mediated Signaling Relaxation Of Vascular Smooth Muscle CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Response To Wounding Negative Regulation Of Smooth Muscle Contraction Regulation Of Platelet Aggregation Inositol Phosphate-mediated Signaling Negative Regulation Of Platelet Activation Negative Regulation Of Muscle Contraction Relaxation Of Muscle Cyclic-nucleotide-mediated Signaling Regulation Of Platelet Activation Vasodilation Endoplasmic Reticulum Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Sequestering Of Calcium Ion Regulation Of Calcium-mediated Signaling Musculoskeletal Movement Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Regulation Of Smooth Muscle Contraction Negative Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C Activity Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Vessel Size Regulation Of Tube Size Intracellular Signal Transduction Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Catalytic Activity Regulation Of Wound Healing Negative Regulation Of Cell-cell Adhesion Energy Reserve Metabolic Process Post-embryonic Development Dendrite Development	Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle
Tagcloud ?		abl attributable ba bcr chromosomal col5a1 cxcl10 dok2 f3 fusions gbp1 gp49b id1 imatinib involve isg20 leukemogenesis microarray offers oligonucleotide overlapping pdgfrb scinderin stat1 switched tel translocations uniquely valpha1	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		abl attributable ba bcr chromosomal col5a1 cxcl10 dok2 f3 fusions gbp1 gp49b id1 imatinib involve isg20 leukemogenesis microarray offers oligonucleotide overlapping pdgfrb scinderin stat1 switched tel translocations uniquely valpha1	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?