MARCHF6 and TRIO

Data Source: HiPPIP (Novel)

		MARCHF6	TRIO
Name		membrane associated ring-CH-type finger 6	trio Rho guanine nucleotide exchange factor
Structure		No pdb structure
GO Annotations	Cellular Component	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment	Cytoplasm Cytosol Extrinsic Component Of Membrane Cell Projection Presynaptic Active Zone Postsynapse Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cholesterol Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		ER Quality Control Compartment (ERQC)	NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
GWAS		No GWAS studies recorded	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Asthma ( 31959851 ) Asthma (childhood onset) ( 31036433 ) Electroencephalogram traits ( 25387704 ) High density lipoprotein cholesterol levels ( 30498476 ) Intake of total sugars ( 31005972 ) Major depressive disorder ( 27777418 ) Paclitaxel-induced neuropathy ( 23776197 ) Physiological dysregulation (Mahalanobis distance) ( 32235003 ) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417 ) Waist circumference ( 28552196 )
Novel Interactors		2 novel interactors: DNAH5 TRIO	5 novel interactors: DAP DNAH5 MARCHF6 NIPBL PRMT7
Interacting Genes		12 interacting genes: ADGRE2 BUD31 DIO2 MSMO1 MTNR1B RGS2 SQLE UBC UBE2D2 UBE2G1 UBE2G2 UBE2J2	13 interacting genes: BLMH CDC42 CDC5L DISC1 DSCR9 EXOC1 FLNA ITSN2 LIMS1 PTK2 PTPRF RAC1 RHOA
Entrez ID		10299	7204
HPRD ID		11095	03537
Ensembl ID		ENSG00000145495	ENSG00000038382
Uniprot IDs		O60337	O75962
PDB IDs		Not available	1NTY 2NZ8 6D8Z 7SJ4
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cholesterol Biosynthetic Process Post-translational Protein Modification ATP Binding Sterol Biosynthetic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Squalene Monooxygenase Activity Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Membrane Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Nucleotide Binding Negative Regulation Of Glycine Import Across Plasma Membrane Proteolysis Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity Thyroid Hormone Catabolic Process Steroid Biosynthetic Process C-4 Methylsterol Oxidase Activity Response To Biphenyl Catabolic Process ERAD Pathway Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adenylate Cyclase Inhibitor Activity	Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Focal Adhesion Cerebral Cortex Cell Migration Cell Motility Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Forebrain Cell Migration Membrane Invagination Positive Regulation Of Cell Migration Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Migration Positive Regulation Of Stress Fiber Assembly Cell Migration Positive Regulation Of Cell Motility Establishment Or Maintenance Of Cell Polarity Non-canonical Wnt Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Locomotion Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Projection Assembly Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cytoskeleton Organization Thioesterase Binding G Protein Activity Cell Projection Organization Protein Kinase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Postsynapse Positive Regulation Of Neuron Migration Establishment Of Cell Polarity Positive Regulation Of Growth Regulation Of Neural Precursor Cell Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Establishment Of Epithelial Cell Apical/basal Polarity